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1. WO2011017162 - METHODS FOR ENHANCING ANTIGEN-SPECIFIC IMMUNE RESPONSES

Publication Number WO/2011/017162
Publication Date 10.02.2011
International Application No. PCT/US2010/043544
International Filing Date 28.07.2010
IPC
A61K 38/16 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
A61K 39/12 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
A61K 31/70 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
C07K 14/025 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
01DNA viruses
025Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61K 2039/5256
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
525Virus
5256expressing foreign proteins
A61K 2039/5258
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
525Virus
5258Virus-like particles
A61K 2039/53
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
53DNA (RNA) vaccination
A61K 31/7088
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
A61K 39/0011
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
0005Vertebrate antigens
0011Cancer antigens
A61K 39/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
Applicants
  • THE JOHNS HOPKINS UNIVERSITY [US]/[US] (AllExceptUS)
  • WU, Tzyy-Choou [US]/[US] (UsOnly)
  • HUNG, Chien-Fu (UsOnly)
  • RODEN, Richard [US]/[US] (UsOnly)
Inventors
  • WU, Tzyy-Choou
  • HUNG, Chien-Fu
  • RODEN, Richard
Agents
  • RUSSELL, Hathaway, P.
Priority Data
61/230,84803.08.2009US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHODS FOR ENHANCING ANTIGEN-SPECIFIC IMMUNE RESPONSES
(FR) MÉTHODES PERMETTANT UN RENFORCEMENT DES RÉPONSES IMMUNITAIRES SPÉCIFIQUES À UN ANTIGÈNE
Abstract
(EN) Methods for delivering naked DNA vaccines to enhance immune responses, by improving transfection efficiency without safety concerns associated with live viral vectors, are described. A method may comprise administering to a mammalian subject an effective amount of a papillomavirus pseudovirion, wherein the papillomavirus pseudovirion comprises at least one papillomavirus capsid protein encapsidating a naked DNA vaccine, wherein the naked DNA vaccine comprises a first nucleic acid encoding at least one antigen, thereby enhancing the antigen specific immune response relative to administration of the naked DNA vaccine.
(FR) La présente invention concerne des méthodes d'administration de vaccins à ADN nu, destinées à renforcer la réponse immunitaire en améliorant l'efficacité de la transfection, mais sans les préoccupations en matière de sécurité éprouvées face aux vecteurs viraux vivants. Une telle méthode peut comprendre les étapes consistant à administrer à un sujet mammifère une quantité efficace d'un pseudovirion de papillomavirus, ledit pseudovirion de papillomavirus comprenant au moins une protéine capsidique de papillomavirus encapsulant un vaccin à ADN nu, ledit vaccin à ADN nu comprenant un premier acide nucléique codant pour au moins un antigène, cela permettant de renforcer la réponse immunitaire spécifique à l'antigène par rapport à l'administration du seul vaccin à ADN nu.
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