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Pub. No.:    WO/2011/017107    International Application No.:    PCT/US2010/043403
Publication Date: 10.02.2011 International Filing Date: 27.07.2010
A61K 38/17 (2006.01), A61K 38/16 (2006.01), C07K 14/47 (2006.01), C12N 15/12 (2006.01), C12N 15/63 (2006.01), A61K 9/08 (2006.01), A61P 35/00 (2006.01)
Applicants: VIRGINIA COMMONWEALTH UNIVERSITY [US/US]; 800 East Leigh Street BioTec One Suite 113 Richmond, Virginia 23219 (US) (For All Designated States Except US).
FISCHER, Paul B. [US/US]; (US) (For US Only).
SARKAR, Devanand [BD/US]; (US) (For US Only).
DASH, Rupesh [IN/US]; (US) (For US Only).
AZAB, Belal Mohammed [JO/US]; (US) (For US Only).
WANG, Xiang-Yang [US/US]; (US) (For US Only).
CLAUDIO, Pier Paolo [--/US]; (US) (For US Only)
Inventors: FISCHER, Paul B.; (US).
SARKAR, Devanand; (US).
DASH, Rupesh; (US).
AZAB, Belal Mohammed; (US).
WANG, Xiang-Yang; (US).
CLAUDIO, Pier Paolo; (US)
Agent: MEYER, Richard S.; Townsend and Townsend and Crew, LLP Two Embarcadero Center Eighth Floor San Francisco, California 94111 (US)
Priority Data:
61/228,721 27.07.2009 US
Abstract: front page image
(EN)Microbubble-assisted delivery of viruses is disclosed. In particular, methods for targeting a virus to cancer cells in an immunocompetent animal by administering a selectively replicating virus to the immunocompetent animal and disrupting the microbubbles in a location of the animal comprising cancer cells are provided. The virus is encompassed in a suspension of microbubbles, and the surface of the suspension does not include any virus. A suspension of microbubbles comprising a selectively replicating virus that is encompassed in a suspension of microbubbles, which does not include any virus on the surface of the suspension, is also provided.
(FR)L'invention porte sur l'administration de virus aidée par microbulle. En particulier, l'invention porte sur des procédés pour cibler un virus dans des cellules cancéreuses dans un animal immunocompétent, par l'administration d'un virus à réplication sélective à l'animal immunocompétent et la rupture des microbulles dans un emplacement de l'animal comprenant des cellules cancéreuses. Le virus est englobé dans une suspension de microbulles et la surface de la suspension ne comprend aucun virus. L'invention porte également sur une suspension de microbulles comprenant un virus à réplication sélective qui est englobé dans une suspension de microbulles, qui ne comprend aucun virus sur la surface de la suspension.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)