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1. (WO2011016861) NOVEL REGULATORY PROTEINS AND INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/016861    International Application No.:    PCT/US2010/002173
Publication Date: 10.02.2011 International Filing Date: 05.08.2010
IPC:
C07K 1/00 (2006.01), C07K 16/00 (2006.01), C12P 21/06 (2006.01)
Applicants: INTRA-CELLULAR THERAPIES, INC. [US/US]; 3690 Broadway New York, NY 10032 (US) (For All Designated States Except US).
GREENGARD, Paul [US/US]; (US) (For US Only).
LOU, Wenjie [US/US]; (US) (For US Only).
HE, Gen [US/US]; (US) (For US Only).
LI, Peng [US/US]; (US) (For US Only).
WENNOGLE, Lawrence [US/US]; (US) (For US Only)
Inventors: GREENGARD, Paul; (US).
LOU, Wenjie; (US).
HE, Gen; (US).
LI, Peng; (US).
WENNOGLE, Lawrence; (US)
Agent: YANG, Arthur; Hoxie & Associates LLC. 75 Main Street, Suite 301 Millburn, NJ 07041 (US)
Priority Data:
61/231,462 05.08.2009 US
Title (EN) NOVEL REGULATORY PROTEINS AND INHIBITORS
(FR) NOUVELLES PROTÉINES RÉGULATRICES ET NOUVEAUX INHIBITEURS
Abstract: front page image
(EN)The disclosure provides a gamma secretase activating protein (gSAP) that activates gamma-secretase to produce beta-amyloid protein (A.beta). Deposition of A.beta has been associated with Alzheimer's disease and other pathologies. The disclosure further provides screening methods, research tools, inhibitors of gSAP, and methods of diagnosis, treatment and control of Alzheimer's disease as well as other neurodegenerative conditions associated with deposition of A.beta.
(FR)L'invention porte sur une protéine jusqu'à présent non caractérisée (protéine d'activation de gamma-secrétase ou gSAP) qui active la γ-secrétase pour produire une protéine β-amyloïde (Aβ). Le dépôt d'Aβ a été associé à la maladie d'Alzheimer et à d'autres pathologies. Ainsi, l'invention porte, de plus, par exemple, sur des procédés de criblage et de nouveaux outils de recherche, sur des inhibiteurs de cette nouvelle protéine et sur des procédés de diagnostic, de traitement et de lutte contre la maladie d'Alzheimer et autres états neurodégénératifs associés au dépôt d'Aβ.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)