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Pub. No.:    WO/2011/016534    International Application No.:    PCT/JP2010/063329
Publication Date: 10.02.2011 International Filing Date: 05.08.2010
A61K 38/00 (2006.01), A61P 11/00 (2006.01), A61P 11/14 (2006.01)
Applicants: THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE [JP/JP]; 6-1, Okubo 1-chome, Kumamoto-shi, Kumamoto 8608568 (JP) (For All Designated States Except US).
Ginkyo Academy Kumamoto Health Science University [JP/JP]; 325 Izumimachi, Kumamoto-shi, Kumamoto 8615598 (JP) (For All Designated States Except US).
NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY [JP/JP]; 2-39-1, Kurokami, Kumamoto-shi, Kumamoto 8608555 (JP) (For All Designated States Except US).
KAMEI, Shintaro [JP/JP]; (JP) (For US Only).
SHINDOME, Asami [JP/JP]; (JP) (For US Only).
HAMAMOTO, Takayoshi [JP/JP]; (JP) (For US Only).
MAEDA, Hiroaki [JP/JP]; (JP) (For US Only).
HIRASHIMA,Masaki [JP/JP]; (JP) (For US Only).
OKUDA, Sachio [JP/JP]; (JP) (For US Only).
UMEHASHI, Misako [JP/JP]; (JP) (For US Only).
OGAWA, Sachie [JP/JP]; (JP) (For US Only).
MAEDA, Megumi [JP/JP]; (JP) (For US Only).
AKAIKE, Norio [JP/JP]; (JP) (For US Only).
TAKAHAMA, Kazuo [JP/JP]; (JP) (For US Only).
WADA, Ryoko [JP/JP]; (JP) (For US Only)
Inventors: KAMEI, Shintaro; (JP).
SHINDOME, Asami; (JP).
HAMAMOTO, Takayoshi; (JP).
MAEDA, Hiroaki; (JP).
OKUDA, Sachio; (JP).
UMEHASHI, Misako; (JP).
OGAWA, Sachie; (JP).
MAEDA, Megumi; (JP).
AKAIKE, Norio; (JP).
TAKAHAMA, Kazuo; (JP).
WADA, Ryoko; (JP)
Agent: TANAKA, Mitsuo; AOYAMA & PARTNERS, IMP Building, 3-7, Shiromi 1-chome, Chuo-ku, Osaka-shi, Osaka 5400001 (JP)
Priority Data:
2009-182945 06.08.2009 JP
(JA) 咳嗽抑制効果を持つ血漿タンパク質
Abstract: front page image
(EN)Disclosed is activated blood coagulation factor XI which can act as an antitussive drug for cough induced by the stimulation of the tracheal bifurcation, such as chronic cough. Specifically disclosed is a pharmaceutical composition for preventing cough, treating cough and/or ameliorating the symptoms of cough, which comprises: a polypeptide chain that comprises a full-length amino acid sequence constituting activated blood coagulation factor XI (also referred to as "FXIa", hereinbelow), an amino acid sequence produced by deleting, substituting or adding one or several amino acid residues in the preceding amino acid sequence, a partial sequence of any one of the aforementioned amino acid sequences, or an amino acid sequence containing any one of the aforementioned amino acid sequences as a part thereof, as an active ingredient; and a pharmacologically acceptable carrier.
(FR)L'invention concerne un facteur de coagulation sanguine activé XI pouvant tenir lieu de médicament antitussif pour une toux induite par la stimulation de la bifurcation trachéale, du type toux chronique. L'invention concerne spécifiquement une composition pharmaceutique de prévention contre la toux, de traitement de la toux et/ou d'amélioration des symptômes de la toux, comprenant: une chaîne polypeptidique à séquence d'acides aminés pleine longueur qui constitue un facteur de coagulation sanguine activé XI (également appelé ci-après "FXIa"), à séquence d'acides aminés produite par suppression, substitution ou adjonction d'un ou plusieurs résidus d'acides aminés dans la séquence précédente, à séquence partielle de l'une quelconque des séquences d'acides aminés susmentionnées, ou à séquence d'acides aminés contenant l'une quelconque des séquences d'acides aminés susmentionnées en tant que partie constitutive, comme principe actif; et un vecteur pharmacologiquement acceptable.
(JA) 慢性咳嗽など気管分岐部刺激に起因する咳に対する鎮咳薬として、活性化血液凝固第XI因子を提供する。有効成分として、活性化血液凝固第XI因子(以下、FXIaと称することもある)を構成する全長のアミノ酸配列、または前記アミノ酸配列のうち1もしくは数個のアミノ酸が欠失、置換もしくは付加されたアミノ酸配列、または前記のいずれかのアミノ酸配列の部分配列、もしくは前記アミノ酸配列を一部に含むアミノ酸配列からなるポリペプチド鎖、および薬理学的に許容しうる担体を含む、咳嗽の予防、治療及び/または症状改善用医薬組成物。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)