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1. (WO2011016239) ANTIBODIES THAT SPECIFICALLY BIND TO A BETA OLIGOMERS AND USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/016239    International Application No.:    PCT/JP2010/004926
Publication Date: 10.02.2011 International Filing Date: 05.08.2010
IPC:
C07K 16/18 (2006.01), A61K 39/395 (2006.01), A61P 25/28 (2006.01), C07K 16/46 (2006.01), C12N 15/09 (2006.01), C12Q 1/02 (2006.01), G01N 33/53 (2006.01)
Applicants: IMMUNAS PHARMA, INC. [JP/JP]; Kanagawa Science Park R&D D11F, 3-2-1, Sakado, Takatsu-ku, Kawasaki-shi, Kanagawa 2130012 (JP) (For All Designated States Except US).
YOKOSEKI, Tatsuki [JP/JP]; (JP) (For US Only).
OKAMOTO, Yasuhide [JP/JP]; (JP) (For US Only).
UMEDA, Makoto [JP/JP]; (JP) (For US Only).
TAKAMATSU, Naofumi [JP/JP]; (JP) (For US Only).
ITO, Toshiyuki [JP/JP]; (JP) (For US Only).
IMAI, Yukiho [JP/JP]; (JP) (For US Only).
FUJII, Shinobu [JP/JP]; (JP) (For US Only)
Inventors: YOKOSEKI, Tatsuki; (JP).
OKAMOTO, Yasuhide; (JP).
UMEDA, Makoto; (JP).
TAKAMATSU, Naofumi; (JP).
ITO, Toshiyuki; (JP).
IMAI, Yukiho; (JP).
FUJII, Shinobu; (JP)
Agent: SHIMIZU, Hatsushi; Kantetsu Tsukuba Bldg. 6F, 1-1-1, Oroshi-machi, Tsuchiura-shi, Ibaraki 3000847 (JP)
Priority Data:
61/231,797 06.08.2009 US
61/282,550 26.02.2010 US
Title (EN) ANTIBODIES THAT SPECIFICALLY BIND TO A BETA OLIGOMERS AND USE THEREOF
(FR) ANTICORPS QUI SE LIENT SPÉCIFIQUEMENT À DES OLIGOMÈRES BÊTA A ET UTILISATION DE CEUX-CI
Abstract: front page image
(EN)The present inventors successfully produced monoclonal antibodies that are specific to only soluble A beta oligomers, but do not recognize soluble A beta monomers, which are physiological molecules. It was demonstrated that the antibodies are useful as diagnostic/therapeutic monoclonal antibodies for Alzheimer's disease.
(FR)Les présents inventeurs ont produit avec succès des anticorps monoclonaux qui sont spécifiques uniquement d'oligomères bêta A solubles, mais ne reconnaissent pas des monomères bêta A solubles, qui sont des molécules physiologiques. Il a été démontré que les anticorps sont utiles en tant qu'anticorps monoclonaux diagnostiques/thérapeutiques pour la maladie d'Alzheimer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)