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1. WO2011016052 - PROCESS FOR PREPARING PREGABALIN

Publication Number WO/2011/016052
Publication Date 10.02.2011
International Application No. PCT/IN2010/000510
International Filing Date 02.08.2010
Chapter 2 Demand Filed 31.05.2011
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
227
Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
04
Formation of amino groups in compounds containing carboxyl groups
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
227
Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
30
Preparation of optical isomers
32
by stereospecific synthesis
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
227
Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
30
Preparation of optical isomers
34
by separation of optical isomers
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
229
Compounds containing amino and carboxyl groups bound to the same carbon skeleton
02
having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
04
the carbon skeleton being acyclic and saturated
06
having only one amino and one carboxyl group bound to the carbon skeleton
08
the nitrogen atom of the amino group being further bound to hydrogen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
13
Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
02
by carboxylic acids
04
having the esterifying carboxyl radicals attached to acyclic carbon atoms
C07C 227/04 (2006.01)
C07C 227/32 (2006.01)
C07C 227/34 (2006.01)
C07C 229/08 (2006.01)
C07H 13/04 (2006.01)
CPC
C07B 2200/07
C07C 227/04
C07C 227/32
C07C 227/34
C07C 229/08
C07H 13/04
Applicants
  • HELVETICA INDUSTRIES (P) LIMITED [IN/IN]; A-1, Community Center Naraina Industrial Area-Phase II New Delhi 110 028, IN (AllExceptUS)
  • PRADHAN, B., S. [IN/IN]; IN (UsOnly)
Inventors
  • PRADHAN, B., S.; IN
Agents
  • TRIPATHI, Vishal; D-22, 2nd Floor Panchsheel Enclave New Delhi 110 017, IN
Priority Data
1221/DEL/201026.05.2010IN
1614/DEL/200903.08.2009IN
2283/DEL/200905.11.2009IN
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PROCESS FOR PREPARING PREGABALIN
(FR) PROCÉDÉ DE PRÉPARATION DE PRÉGABALINE
Abstract
(EN)
The invention relates to a process for preparing a compound of formula (I): wherein said process comprises hydrogenation of a compound of formula (II): under alkaline conditions, wherein R represents hydrogen or a labile group capable of being converted to hydrogen. The invention also relates to intermediates used in said process, to the use of said intermediates in the preparation of pregabalin and to a process for resolving racemic compounds of formula (I).
(FR)
La présente invention concerne un procédé de préparation d'un composé de formule (I), ledit procédé comprenant l'hydrogénation d'un composé de formule (II) dans des conditions alcalines; R représentant hydrogène ou un groupe labile pouvant être converti hydrogène. Cette invention porte également sur des intermédiaires utilisés dans ledit procédé, sur l'utilisation de ces intermédiaires dans la préparation de prégabaline et sur un procédé de résolution de composés racémiques de formule (I).
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