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1. (WO2011015573) MOLECULAR TARGETS AND COMPOUNDS, AND METHODS TO IDENTIFY THE SAME, USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISEASES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2011/015573 International Application No.: PCT/EP2010/061274
Publication Date: 10.02.2011 International Filing Date: 03.08.2010
IPC:
G01N 33/50 (2006.01) ,G01N 33/68 (2006.01) ,A61K 48/00 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Applicants:
FISCHER, David, Frederik [NL/NL]; NL (UsOnly)
DE PRIL, Remko, [NL/NL]; NL (UsOnly)
VAN STEENHOVEN, Desiré, Maria, Petronella, Catharina [NL/NL]; NL (UsOnly)
JANSSEN, Richard, Antonius, Jozef [NL/CH]; CH (UsOnly)
KWAK, Seung [US/US]; US (UsOnly)
HOWLAND, David [US/US]; US (UsOnly)
SIGNER, Ethan [US/US]; US (UsOnly)
GALAPAGOS NV [BE/BE]; General De Wittelaan L11/A3 2800 Mechelen Belgium, BE (AllExceptUS)
Inventors:
FISCHER, David, Frederik; NL
DE PRIL, Remko,; NL
VAN STEENHOVEN, Desiré, Maria, Petronella, Catharina; NL
JANSSEN, Richard, Antonius, Jozef; CH
KWAK, Seung; US
HOWLAND, David; US
SIGNER, Ethan; US
Agent:
TEUTEN, Andrew; Sagittarius IP Taylor House 39 High Street Marlow Buckinghamshire SL7 1AF, GB
Priority Data:
61/273,30603.08.2009US
Title (EN) MOLECULAR TARGETS AND COMPOUNDS, AND METHODS TO IDENTIFY THE SAME, USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISEASES
(FR) CIBLES ET COMPOSÉS MOLÉCULAIRES, ET PROCÉDÉS POUR LES IDENTIFIER, UTILES DANS LE TRAITEMENT DE MALADIES NEURODÉGÉNÉRATIVES
Abstract:
(EN) The present invention relates to methods and assays for identifying agents capable of inhibiting the mutant huntingtin protein, inhibiting or reducing cell death, in particular cell death associated with polyglutamine-induced protein aggregation, which inhibition is useful in the prevention, amelioration and/or treatment of neurodegenerative diseases, and Huntington's disease more generally. In particular, the present invention provides methods and assays for identifying agents for use in the prevention and/or treatment of Huntington's disease. The invention provides polypeptide and nucleic acid TARGETs and siRNA sequences based on these TARGETs.
(FR) La présente invention a pour objet des procédés et des analyses pour l'identification d'agents capables d'inhiber la protéine huntingtine mutante, d'inhiber ou de réduire la mort cellulaire, en particulier la mort cellulaire associée à une agrégation de protéine induite par la polyglutamine, laquelle inhibition est utile dans la prévention, l'amélioration et/ou le traitement de maladies neurodégénératives, et de la maladie de Huntington de manière plus générale. En particulier, la présente invention concerne des procédés et des analyses pour l'identification d'agents destinés à être utilisés dans la prévention et/ou le traitement de la maladie de Huntington. La présente invention concerne des CIBLES polypeptide et acide nucléique et des séquences d'ARNsi basées sur ces CIBLES.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)