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1. (WO2011013703) PANCREATIC ENDOCRINE CELL INDICATOR AND UTILIZATION OF SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/013703    International Application No.:    PCT/JP2010/062701
Publication Date: 03.02.2011 International Filing Date: 28.07.2010
IPC:
A61K 51/00 (2006.01), A61K 38/22 (2006.01), G01N 33/53 (2006.01), G01N 33/531 (2006.01), G01N 33/534 (2006.01)
Applicants: RIKEN [JP/JP]; 2-1, Hirosawa, Wako-shi, Saitama 3510198 (JP) (For All Designated States Except US).
WATANABE, Yasuyoshi [JP/JP]; (JP) (For US Only).
SAKO, Takeo [JP/JP]; (JP) (For US Only).
HASEGAWA, Koki [JP/JP]; (JP) (For US Only).
KANAYAMA, Yousuke [JP/JP]; (JP) (For US Only).
KATAOKA, Yousuke [JP/JP]; (JP) (For US Only)
Inventors: WATANABE, Yasuyoshi; (JP).
SAKO, Takeo; (JP).
HASEGAWA, Koki; (JP).
KANAYAMA, Yousuke; (JP).
KATAOKA, Yousuke; (JP)
Agent: HARAKENZO WORLD PATENT & TRADEMARK; Daiwa Minamimorimachi Building, 2-6, Tenjinbashi 2-chome Kita, Kita-ku, Osaka-shi, Osaka 5300041 (JP)
Priority Data:
2009-179935 31.07.2009 JP
Title (EN) PANCREATIC ENDOCRINE CELL INDICATOR AND UTILIZATION OF SAME
(FR) MARQUEUR DES CELLULES ENDOCRINES DU PANCRÉAS ET SON UTILISATION
(JA) 膵臓内分泌細胞用指示薬、及びその利用
Abstract: front page image
(EN)Disclosed is a pancreatic endocrine cell indicator comprising a modified polypeptide, in which a metal chelator is attached exclusively to an amino acid that is located at a site other than the somatostatin receptor-binding active site in a polypeptide selected from the group consisting of somatostatin and somatostatin analogs, and a radioactive metal nuclide that is held by said metal chelator. Thus, a novel pancreatic endocrine cell indicator can be provided.
(FR)La présente invention concerne un marqueur des cellules endocrines du pancréas comprenant un polypeptide modifié, dans lequel un chélateur métallique est fixé, de façon exclusive, à un acide aminé situé en un site autre que le site actif de liaison du récepteur à la somatostatine dans un polypeptide choisi dans le groupe constitué de la somatostatine et des analogues de la somatostatine, et dans lequel un nucléide métallique radioactif est retenu par ledit chélateur métallique. C'est ainsi que l'on peut obtenir un marqueur inédit des cellules endocrines du pancréas.
(JA) 本発明の膵臓内分泌細胞用指示薬は、ソマトスタチン及びソマトスタチンのアナログからなる群より選択されるポリペプチドにおける、ソマトスタチン受容体との結合活性部位以外に位置するアミノ酸に対してのみ金属キレーターが結合されてなる修飾ポリペプチドと、当該金属キレーターに保持された放射性の金属核種と、を含んでなる。よって、本発明によれば、新規な膵臓内分泌細胞用指示薬を提供することができる。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)