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1. (WO2011013639) TABLET
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/013639    International Application No.:    PCT/JP2010/062568
Publication Date: 03.02.2011 International Filing Date: 27.07.2010
A61K 31/506 (2006.01), A61K 9/20 (2006.01), A61K 47/04 (2006.01), A61K 47/38 (2006.01)
Applicants: TAKEDA PHARMACEUTICAL COMPANY LIMITED [JP/JP]; 1-1, Doshomachi 4-chome, Chuo-ku, Osaka-shi, Osaka 5410045 (JP) (For All Designated States Except US).
MURAKAWA, Yusuke [JP/GB]; (GB) (For US Only).
OKABE, Takayuki [JP/JP]; (JP) (For US Only)
Inventors: MURAKAWA, Yusuke; (GB).
OKABE, Takayuki; (JP)
Agent: TAKASHIMA, Hajime; Meiji Yasuda Seimei Osaka Midosuji Bldg., 1-1, Fushimimachi 4-chome, Chuo-ku, Osaka-shi, Osaka 5410044 (JP)
Priority Data:
2009-175695 28.07.2009 JP
(JA) 錠剤
Abstract: front page image
(EN)Disclosed is a high-dose tablet which contains 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)- pyrimidinyl]methyl]-4-fluorobenzonitrile (compound (A)) or a salt thereof as a pharmaceutically active ingredient. Specifically disclosed is a tablet which contains the compound (A) or a salt thereof, and a fluidizer, with the content of the compound (A) being 35-50% by weight.
(FR)La présente invention concerne un comprimé fortement dosé contenant du 2-[[6-[(3R)-3-amino-1-pipéridinyl]-3,4-dihydro-3-méthyl-2,4-dioxo-1(2H)- pyrimidinyl]méthyl]-4-fluorobenzonitrile (composé (A)), ou un sel de celui-ci, en tant que principe actif pharmaceutique. L'invention concerne, plus précisément, un comprimé contenant le composé (A), ou un sel de celui-ci, et un fluidifiant, la teneur en composé (A) étant égale à 35 à 50 % en poids.
(JA) 2-[[6-[(3R)-3-アミノ-1-ピペリジニル]-3,4-ジヒドロ-3-メチル-2,4-ジオキソ-1(2H)-ピリミジニル]メチル]-4-フルオロベンゾニトリル(化合物(A))またはその塩を医薬活性成分とする高用量の錠剤を提供する。化合物(A)またはその塩、および流動化剤を含有し、かつ、化合物(A)の含量が35~50重量%である、錠剤。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)