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1. (WO2011012912) NEW GRANULATING PROCESS AND THUS PREPARED GRANULATE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/012912    International Application No.:    PCT/HU2010/000022
Publication Date: 03.02.2011 International Filing Date: 24.02.2010
IPC:
A61K 9/16 (2006.01), A61K 9/20 (2006.01), A61K 9/50 (2006.01), A61K 31/397 (2006.01), A61K 45/06 (2006.01)
Applicants: EGIS GYÓGYSZERGYÁR NYILVÁNOSAN MŰKÖDŐ RÉSZVÉNYTÁRSASÁG [HU/HU]; Keresztúri út 30-38 H-1106 Budapest (HU) (For All Designated States Except US).
TÖLGYESI, Zoltán [HU/HU]; (HU) (For US Only).
ZSIGMOND, Zsolt [HU/HU]; (HU) (For US Only).
ÚJFALUSSY, György [HU/HU]; (HU) (For US Only).
LEVENTISZNÉ HUSZÁR, Magdolna [HU/HU]; (HU) (For US Only).
TONKA-NAGY, Péter [HU/HU]; (HU) (For US Only).
AGYAGOS, Mónika [HU/HU]; (HU) (For US Only)
Inventors: TÖLGYESI, Zoltán; (HU).
ZSIGMOND, Zsolt; (HU).
ÚJFALUSSY, György; (HU).
LEVENTISZNÉ HUSZÁR, Magdolna; (HU).
TONKA-NAGY, Péter; (HU).
AGYAGOS, Mónika; (HU)
Agent: ADVOPATENT OFFICE OF PATENT AND TRADEMARK ATTORNEYS; P.O. Box 80 H-1255 Budapest (HU)
Priority Data:
P 09 00468 28.07.2009 HU
P 10 00044 25.01.2010 HU
Title (EN) NEW GRANULATING PROCESS AND THUS PREPARED GRANULATE
(FR) NOUVEAU PROCÉDÉ DE GRANULATION ET GRANULÉ AINSI PRÉPARÉ
Abstract: front page image
(EN)The present invention relates to a process for manufacturing microcrystalline ezetimibe containing granulate, wherein a) ezetimibe is dissolved; b) the dissolved ezetimibe is precipitated with water, which if necessary contains pharmaceutical excipients, preferably lauryl-sulfate derivatives, and c) granulates are formed from the obtained suspension by spraying the suspension onto pharmaceutical excipients. A further aspect of the present invention is the granulate obtained by the present process and the pharmaceutical composition containing such granulate.
(FR)La présente invention porte sur un procédé pour fabriquer un granulat contenant de l'ézétimibe monocristalline, dans lequel procédé a) de l'ézétimibe est dissoute; b) l'ézétimibe dissoute est précipitée avec de l'eau, qui, si nécessaire, contient des excipients pharmaceutiques, de préférence des dérivés du lauryl-sulfate, et c) des granulés sont formés à partir de la suspension obtenue par pulvérisation de la suspension sur des excipients pharmaceutiques. La présente invention, selon un autre aspect, porte sur le granulé obtenu par le présent procédé et sur la composition pharmaceutique contenant ce granulé.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: Hungarian (HU)