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Pub. No.:    WO/2011/012850    International Application No.:    PCT/GB2010/001422
Publication Date: 03.02.2011 International Filing Date: 26.07.2010
A61K 47/48 (2006.01)
Applicants: LIPOXEN TECHNOLOGIES LIMITED [GB/GB]; London Bioscience Innovation Centre 2 Royal College Street London NW1 0NH (GB) (For All Designated States Except US).
JAIN, Sanjay [GB/GB]; (GB) (For US Only).
GREGORIADIS, Gregory [CA/GB]; (GB) (For US Only).
DWIVEDI, Archana [IN/GB]; (GB) (For US Only).
NATH, Srijit [IN/GB]; (GB) (For US Only).
SIEKMANN, Juergen [DE/AT]; (AT) (For US Only).
HAIDER, Stefan [AT/AT]; (AT) (For US Only).
ROTTENSTEINER, Hanspeter [AT/AT]; (AT) (For US Only).
TURECEK, Peter [AT/AT]; (AT) (For US Only).
BAXTER INTERNATIONAL INC. [US/US]; One Baxter Parkway Deerfield Illinois 60015 (US) (For All Designated States Except US).
BAXTER HEALTHCARE S.A. [CH/CH]; Thurgauerstrasse 130 CH-8152 Glattpark (CH) (For All Designated States Except US)
Inventors: JAIN, Sanjay; (GB).
DWIVEDI, Archana; (GB).
NATH, Srijit; (GB).
SIEKMANN, Juergen; (AT).
HAIDER, Stefan; (AT).
TURECEK, Peter; (AT)
Agent: SCHLICH, George William; Schlich & Co 34 New Road Littlehampton West Sussex BN 17 5AT (GB)
Priority Data:
61/228,828 27.07.2009 US
61/347,136 21.05.2010 US
Abstract: front page image
(EN)A water soluble polymer, in particular polysialic acid (PSA) or a modified PSA (mPSA), is conjugated to an oxidized carbohydrate moiety of a glycoprotein other than a blood coagulation protein or to a ganglioside or drug delivery system by contacting the oxidized carbohydrate moiety with the water soluble polymer, wherein said water soluble polymer contains an aminooxy group and an oxime linkage is formed between the oxidized carbohydrate moiety and the aminooxy group on the water soluble polymer or wherein said water soluble polymer contains a hydrazide group and a hydrazone linkage is formed between the oxidized carbohydrate moiety and the hydrazide group on the water soluble polymer. Conjugates of aminooxy- or hydrazide-water soluble polymer, such as PSA and mPSA, are thus obtained in which the PSA or mPSA is attached via a carbohydrate moiety.
(FR)La présente invention concerne un polymère soluble aqueux, en particulier un acide polysialique (PSA) ou un PSA modifié (mPSA), conjugué à une partie de carbohydrate oxydé d'une glycoprotéine autre qu'une protéine de coagulation sanguine, ou à un ganglioside ou à un système d'administration de médicament, par la mise en contact de la partie de carbohydrate oxydé et d'un polymère hydrosoluble. Ledit hydropolymère contient un groupe aminooxy et une liaison oxime est formée entre la partie de carbohydrate oxydé et le groupe aminooxy sur le polymère hydrosoluble, ou ledit polymère hydrosoluble contient un groupe hydrazide et une liaison hydrazone est formée entre la partie de carbohydrate oxydée et le groupe hydrazide sur le polymère hydrosoluble. On obtient ainsi des conjugués de polymère hydrosoluble-aminooxy ou -hydrazide, tels que le PSA et le mPSA, dans lesquels le PSA ou le mPSA est attaché via une partie de carbohydrate.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)