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1. (WO2011012824) NOVEL NITROREDUCTASE ENZYMATIC SUBSTRATES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/012824    International Application No.:    PCT/FR2010/051621
Publication Date: 03.02.2011 International Filing Date: 29.07.2010
IPC:
C12Q 1/04 (2006.01), C12Q 1/26 (2006.01)
Applicants: BIOMÉRIEUX [FR/FR]; Chemin de l'Orme F-69280 Marcy L'etoile (FR) (For All Designated States Except US).
FABREGA, Olivier [FR/GB]; (GB) (For US Only).
JAMES, Arthur [GB/GB]; (GB) (For US Only).
ORENGA, Sylvain [FR/FR]; (FR) (For US Only).
PERRY, John [GB/GB]; (GB) (For US Only).
SALWATURA, Vindhya, Lakshika [LK/GB]; (GB) (For US Only).
STANFORTH, Stephen [GB/GB]; (GB) (For US Only)
Inventors: FABREGA, Olivier; (GB).
JAMES, Arthur; (GB).
ORENGA, Sylvain; (FR).
PERRY, John; (GB).
SALWATURA, Vindhya, Lakshika; (GB).
STANFORTH, Stephen; (GB)
Agent: BLOND, Jean-Luc; BioMérieux Dpt Propriété Industrielle chemin de l'Orme F-69280 Marcy L'etoile (FR)
Priority Data:
09/03756 30.07.2009 FR
Title (EN) NOVEL NITROREDUCTASE ENZYMATIC SUBSTRATES
(FR) NOUVEAUX SUBSTRATS ENZYMATIQUES DE NITROREDUCTASE
Abstract: front page image
(EN)The invention relates to the use of a compound having formula (I) as an enzymatic substrate for the detection of a nitroreductase activity, wherein: W1, W2, W3 and W4 are independently H, Br, Cl, F, I, alkyl, alkoxy, thiomethyl, perfluoroalkyl, nitro, cyano, carboxyl (including the esters or amides thereof) or any combination of same; n = 0, 1 or 2; U is N or N+R and V is CZ6 N or N+R or V is N or N+R and U is CZ6, R being H, alkyl, aralkyl, aryl, alkanoic or alkylsulphonic; and Z1, Z2, Z3, Z4, Z5 and Z6 are independently H, Br, Cl, F, I, alkyl, aryl, alkoxy, perfluoroalkyl, nitro, cyano, carboxyl, sulphonyl, including the sulphonyl or carboxyl amides or esters thereof, and the salts of same.
(FR)L'invention concerne l'utilisation d'un composé de la formule (I) suivante, comme substrat enzymatique pour la détection d'une activité nitroréductase :Formule (I) selon laquelle : • W1, W2, W3 et W4 sont indépendamment H, Br, C1, F, I, alkyle, alkoxy, thiométhyle, perfluoroalkyle, nitro, cyano, carboxyle (incluant ses esters ou amides) ou toute combinaison de ceux-ci • n = 0, 1 ou 2 • U est N ou N+R et V est CZ6 N ou N+R ou V est N ou N+R et U est CZ6, R étant H, alkyle, aralkyle, aryle, alcanoïque ou alkylsulfonique • Z1, Z2, Z3, Z4, Z5 et Z6 étant indépendamment H, Br, C1, F, I, alkyle, aryle, alkoxy, perfluoroalkyle, nitro, cyano, carboxyle, sulfonyle, incluant les esters ou amides de carboxyle ou sulfonyle et leurs sels.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: French (FR)
Filing Language: French (FR)