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Pub. No.:    WO/2011/012809    International Application No.:    PCT/FR2010/051597
Publication Date: 03.02.2011 International Filing Date: 28.07.2010
C12Q 1/04 (2006.01), C12Q 1/37 (2006.01), G01N 33/84 (2006.01)
Applicants: BIOMÉRIEUX [FR/FR]; Chemin de l'Orme F-69280 Marcy L'etoile (FR) (For All Designated States Except US).
FABREGA, Olivier [FR/GB]; (GB) (For US Only).
JAMES, Arthur [GB/GB]; (GB) (For US Only).
ORENGA, Sylvain [FR/FR]; (FR) (For US Only).
PERRY, John [GB/GB]; (GB) (For US Only).
SALWATURA, Vindhya Lakshika [LK/GB]; (GB) (For US Only).
STANFORTH, Stephen [GB/GB]; (GB) (For US Only)
Inventors: FABREGA, Olivier; (GB).
JAMES, Arthur; (GB).
ORENGA, Sylvain; (FR).
PERRY, John; (GB).
SALWATURA, Vindhya Lakshika; (GB).
STANFORTH, Stephen; (GB)
Agent: BLOND, Jean-Luc; bioMérieux Dpt Propriété Industrielle chemin de l'Orme F-69280 Marcy L'etoile (FR)
Priority Data:
0903768 30.07.2009 FR
Abstract: front page image
(EN)The present invention relates to the use of a compound of the following formula (I), as an enzyme substrate for the detection of a peptidase activity or as a pH indicator: according to which: • Y1 is a peptide, H or an alkyl • W1, W2, W3 and W4 are independently H, Br, Cl, F, I, alkyl, alkoxy, thiomethyl, perfluoroalkyl, nitro, cyano, carboxyl (including the esters or amides thereof) or any combination thereof • n = 0, 1 or 2 • U is N or N+R and V is CZ6 N or N+R or else V is N or N+R and U is CZ6, • R is H, alkyl, aralkyl, aryl, alkanoic or alkylsulphonic • Z1, Z2, Z3, Z4 and Z5 are independently H, Br, Cl, F, I, alkyl, aryl, alkoxy, perfluoroalkyl, nitro, cyano, carboxyl, sulphonyl, including the carboxyl or sulphonyl esters or amides and salts thereof.
(FR)La présente invention concerne l'utilisation d'un composé de la formule (I) suivante, comme substrat enzymatique pour la détection d'une activité peptidase ou comme indicateur de pH : selon laquelle : • Y1 est un peptide, H ou un alkyl • W1, W2, W3 et W4 sont indépendamment H, Br, Cl, F, I, alkyle, alkoxy, thiométhyle, perfluoroalkyle, nitro, cyano, carboxyle (incluant ses esters ou amides) ou toute combinaison de ceux-ci • n = 0, 1 ou 2 • U est N ou N+R et V est CZ6 N ou N+R ou bien V est N ou N+R et U est CZ6, • R est H, alkyle, aralkyle, aryle, alcanoïque ou alkylsulfonique • Z1, Z2, Z3, Z4 et Z5, sont indépendamment H, Br, Cl, F, I, alkyle, aryle, alkoxy, perfluoroalkyle, nitro, cyano, carboxyle, sulfonyle, incluant les esters ou amides de carboxyle ou sulfonyle et leurs sels.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: French (FR)
Filing Language: French (FR)