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1. WO2011011317 - VITAMIN C AND VITAMIN K, AND COMPOSITIONS THEREOF FOR TREATMENT OF OSTEOLYSIS OR PROLONGATION OF PROSTHETIC IMPLANT

Publication Number WO/2011/011317
Publication Date 27.01.2011
International Application No. PCT/US2010/042427
International Filing Date 19.07.2010
IPC
A01N 43/08 2006.01
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
43Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
02having rings with one or more oxygen or sulfur atoms as the only ring hetero atom
04with one hetero atom
06five-membered rings
08with oxygen as the ring hetero atom
A61K 31/34 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
34having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
CPC
A61K 31/122
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
12Ketones
122having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
A61K 31/185
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
A61K 31/375
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
365Lactones
375Ascorbic acid, i.e. vitamin C; Salts thereof
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61K 9/0019
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
A61K 9/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
08Solutions
Applicants
  • SUMMA HEALTH SYSTEM [US]/[US] (AllExceptUS)
  • JAMISON, James, M. [US]/[US] (UsOnly)
  • MILLER, Thomas, M. [US]/[US] (UsOnly)
  • NEAL, Deborah, R. [US]/[US] (UsOnly)
  • KOVACIK, Mark, William [US]/[US] (UsOnly)
  • ASKEW, Michael, John [US]/[US] (UsOnly)
  • MOSTARDI, Richard, Albert [US]/[US] (UsOnly)
Inventors
  • JAMISON, James, M.
  • MILLER, Thomas, M.
  • NEAL, Deborah, R.
  • KOVACIK, Mark, William
  • ASKEW, Michael, John
  • MOSTARDI, Richard, Albert
Agents
  • INSOGNA, Anthony, M.
Priority Data
61/227,04120.07.2009US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) VITAMIN C AND VITAMIN K, AND COMPOSITIONS THEREOF FOR TREATMENT OF OSTEOLYSIS OR PROLONGATION OF PROSTHETIC IMPLANT
(FR) VITAMINE C ET VITAMINE K, ET COMPOSITIONS EN CONTENANT UTILISABLES DANS LE CADRE DU TRAITEMENT DE L'OSTÉOLYSE OU DU PROLONGEMENT DE LA DURÉE DE VIE D'UN IMPLANT PROTHÉTIQUE
Abstract
(EN)
Provided herein is a method of treating, preventing, or managing osteolysis in a subject, comprising administering to the subject a therapeutically effective amount of vitamin C, or a pharmaceutically acceptable salt, solvate, or hydrate thereof, in combination with vitamin K, or a single enantiomer, a mixture of enantiomers, or a mixture of diastereomers thereof, or a pharmaceutically acceptable salt, solvate, or hydrate thereof.
(FR)
La présente invention concerne une méthode de traitement, de prévention ou de prise en charge de l'ostéolyse chez un sujet. Ladite méthode comprend une étape consistant à administrer au sujet une quantité thérapeutiquement efficace de vitamine C, ou d'un solvate, hydrate ou sel pharmaceutiquement acceptable de celle-ci, en association avec de la vitamine K, ou un énantiomère unique, un mélange d'énantiomères ou un mélange de diastéréoisomères de celle-ci, ou, encore, avec un solvate, un hydrate ou un sel pharmaceutiquement acceptable de celle-ci.
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