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1. WO2011010103 - METHODS AND USES

Publication Number WO/2011/010103
Publication Date 27.01.2011
International Application No. PCT/GB2010/001394
International Filing Date 22.07.2010
IPC
G01N 33/94 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
94involving narcotics
CPC
G01N 2800/00
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
G01N 2800/52
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
52Predicting or monitoring the response to treatment; Prognosis
G01N 33/9486
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
94involving narcotics ; or drugs or pharmaceuticals, neurotransmitters or associated receptors
9486Analgesics, e.g. opiates, aspirine
Applicants
  • IMPERIAL INNOVATIONS LIMITED [GB]/[GB] (AllExceptUS)
  • NICHOLSON, Jeremy, Kirk [GB]/[GB] (UsOnly)
  • HOLMES, Elaine [GB]/[GB] (UsOnly)
  • LINDON, John, Christopher [GB]/[GB] (UsOnly)
Inventors
  • NICHOLSON, Jeremy, Kirk
  • HOLMES, Elaine
  • LINDON, John, Christopher
Agents
  • MILES, John
Priority Data
0912744.022.07.2009GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS AND USES
(FR) MÉTHODES ET UTILISATIONS
Abstract
(EN)
The invention provides a method for classifying an individual, the method comprising assessing any one or more of (a) a bacterial metabolite conjugated to a sulfur-containing moiety (b) a cresol metabolite and (c) overall sulfur concentration and/or distribution of sulfur atoms in molecules in a sample taken from the individual, wherein when assessing para-cresol sulfate the individual is not classified according to whether or not the individual has multiple sclerosis, when assessing hippurate and/or 4-hydroxyhippurate the individual is not classified according to whether the individual has autism spectrum disorder or not, and when assessing para-cresol the individual is not classified according to whether or not the individual has hyperactivity.
(FR)
Cette invention concerne une méthode de répartition d'un sujet dans une catégorie, ladite méthode consistant à analyser une ou plusieurs des entités suivantes : (a) un métabolite bactérien conjugué à une fraction soufrée ; (b) un métabolite du crésol ; et (c) la concentration globale en soufre et/ou la répartition des atomes de soufre dans les molécules d'un échantillon prélevé chez le sujet, l'analyse du conjugué sulfaté du para‑crésol ne servant pas classer le sujet dans ou à l'éliminer de la catégorie des sujets atteints de sclérose en plaques, l'analyse de l'hippurate et/ou du 4-hydroxyhippurate ne servant pas classer le sujet dans ou à l'éliminer de la catégorie des sujets souffrant de troubles autistiques, et l'analyse du para-crésol ne servant pas le classer dans ou à l'éliminer de la catégorie des sujets hyperactifs.
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