Processing

Please wait...

Settings

Settings

Goto Application

1. WO2011008972 - SYSTEMS FOR BIOAGENT IDENTIFICATION

Note: Text based on automatic Optical Character Recognition processes. Please use the PDF version for legal matters

[ EN ]

CLAIMS

WE CLAIM

1. A system, comprising:

at least one sample container handling component that comprises at least one non-priority sample container storage unit and at least one priority sample container storage unit that each store at least one sample container that is configured to contain one or more samples;

at least one mixing station that comprises at least one mixing container and at least one mixing mechanism that is configured to mix at least one composition comprising magnetically responsive particles disposed in the mixing container;

at least one sample processing component that comprises:

at least one sample processing unit that comprises:

at least one sample processing vessel that is configured to contain at least one sample comprising at least one magnetically responsive particle;

at least one magnet that generates, or is configured to generate, at least one magnetic field at least proximal to the sample processing vessel; and at least one carrier mechanism operably connected to the sample processing unit, which carrier mechanism is configured to move the sample processing unit to one or more locations;

at least one detection component that is configured to detect at least one detectable property of at least one sample component;

at least one material transfer component that is configured to transfer material to and/or from the sample container handling component, the mixing station, the sample processing component, and/or the detection component; and,

at least one controller operably connected to, and configured to effect operation of, the sample container handling component, the mixing station, the sample processing component, and/or the detection component.

2. The system of claim 1 , wherein the non-priority sample container storage unit and the priority sample container storage unit are each configured to store at least one microplate.

3. The system of claim 1, wherein the sample processing vessel comprises at least one cuvette.

4. The system of claim 1 , wherein the magnet is in a substantially fixed position.

5. The system of claim 1, wherein the detection component comprises at least one mass spectrometer.

6. The system of claim 1, wherein the detection component comprises at least one biopolymer sequencing component.

7. The system of claim 1, comprising at least one sample preparation component and/or at least one nucleic acid amplification component.

8. The system of claim 1, comprising at least one database.

9. The system of claim 1, comprising:

at least one sample container processing area;

at least one non-priority sample container holding area; and,

at least one sample container transport mechanism that is configured to transport one or more sample containers between the non-priority sample container storage unit, the priority sample container storage unit, the priority sample container storage unit, the sample container processing area, and/or the non-priority sample container holding area.

10. The system of claim 9, wherein the controller is configured to selectively direct the sample container transport mechanism to:

transport a non-priority sample container from the non-priority sample container storage unit to the sample container processing area;

position the non-priority sample container while in the sample container processing area; transport the non-priority sample container from the sample container processing area to the non-priority sample container holding area when a priority sample container is stored in the priority sample container storage unit;

transport the priority sample container from the priority sample container storage unit to the sample container processing area;

position the priority sample container while in the sample container processing area; transport the priority sample container from the sample container processing area to the non-priority sample container storage unit or to the priority sample container storage unit; transport the non-priority sample container from the non-priority sample container holding area to the sample container processing area; and

transport the non-priority sample container from the sample container processing area to the non-priority sample container storage unit.

11. The system of claim 1, wherein the mixing container comprises a cartridge that comprises:

at least one body structure comprising one or more surfaces that define a cavity having upper and lower portions;

at least one rotatable member extending at least partially along an axis that is substantially horizontally disposed in the upper portion of the cavity; and

at least one protrusion extending outward from the rotatable member and into the lower portion of the cavity.

12. The system of claim 11, wherein the mixing mechanism comprises at least one cartridge receiver/rotation assembly that comprises:

at least one cartridge support structure that supports the body structure of the cartridge; and

a rotational mechanism operably connected to the rotatable member.

13. The system of claim 12, wherein the controller is configured to selectively direct the rotational mechanism to rotate the rotatable member in an initiation mode or in a maintenance mode, wherein a rate of rotation of the rotatable member is greater in the initiation mode than in the maintenance mode.

14. The system of claim 1 , wherein the sample processing unit comprises:

at least a first motor operably connected to the sample processing vessel, which first motor is configured to rotate the sample processing vessel around a central longitudinal axis of the sample processing vessel;

at least one support member operably connected to the first motor; and,

at least a second motor operably connected to the support member, which second motor is configured to rotate the sample processing vessel between at least first and second positions, wherein at least the first position is within magnetic communication with the magnet when the magnet generates the magnetic field.

15. The system of claim 14, wherein the controller is configured to effect one or more of: the magnet to generate the magnetic field, the first motor to rotate the sample processing vessel, the second motor to rotate the sample processing vessel between the first and second positions, the carrier mechanism to move the sample processing unit to the one or more locations, or the material transfer component to transfer the material to and/or from the sample processing vessel.

16. The system of claim 14, wherein the controller is configured to effect the first motor to rotate the sample processing vessel in one or more selectable modes.

17. A system, comprising:

a) a sample processing unit comprising a magnet;

b) a container for containing a reagent housed in said sample processing unit; and c) a sample transfer component for transferring reagent from said container to a different region of said sample processing unit; wherein said sample transfer component comprises a channel configured to withdraw reagent from said container, said channel comprising a metal base and a non-metal tip.

18. The system of claim 17, wherein said non-metal tip is a plastic or ceramic tip.

19. The system of claim 17, wherein said container houses said reagent.

20. The system of claim 19, wherein said reagent comprises magnetic particles.

21. A system, comprising:

a) a reagent housing component configured to house a plurality of reagent containers, said reagent housing component having a capacitive level sensor that measures the level of reagent in said reagent containers, said reagent housing component having an alarm system, said alarm system configured to generate a signal identifying one or more of said reagent containers falling above or below a predetermined threshold level of reagent, said level identify by said capacitive level sensor;

b) a sample processing unit configured to process a biological sample using said reagents;

c) a reagent transfer mechanism for transferring reagents from one or more of said plurality of reagent containers to said sample processing unit; and

d) a housing covering said sample processing unit and at least part of said reagent housing component and said reagent transfer mechanism; said housing having an alarm display that displays a signal on the visible from the outer surface of said housing, said alarm display being triggered if any one or more of said reagent housing components falls above or below said predetermined threshold level.

22. The system of claim 21, wherein said alarm system comprises a light located under each of said reagent containers, wherein said lights are configured to identify individual members of said plurality of containers that fall above or below said predetermined threshold level.

23. The system of claim 21, wherein said alarm display comprises one or more colored lights.

24. The system of claim 21, wherein said reagent housing component is removably contained within said housing.