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1. WO2011008915 - PYRROLOPYRIDINE INHIBITORS OF KINASES

Publication Number WO/2011/008915
Publication Date 20.01.2011
International Application No. PCT/US2010/042067
International Filing Date 15.07.2010
IPC
C07D 471/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61K 31/437 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
437the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 35/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
02specific for leukemia
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C07D 471/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • ABBOTT LABORATORIES [US]/[US] (AllExceptUS)
  • FLORJANCIC, Alan [US]/[US] (UsOnly)
  • TONG, Yunsong [CN]/[US] (UsOnly)
  • PENNING, Thomas [US]/[US] (UsOnly)
Inventors
  • FLORJANCIC, Alan
  • TONG, Yunsong
  • PENNING, Thomas
Agents
  • BECKER, Cheryl, L.
Priority Data
61/225,74215.07.2009US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) PYRROLOPYRIDINE INHIBITORS OF KINASES
(FR) PYRROLOPYRIDINES INHIBITEURS DE KINASES
Abstract
(EN) The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, formula (I) wherein R1a, R1b, R1c, X, and Y are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.
(FR) La présente invention porte sur des composés de formule (I) ou sur leurs sels pharmaceutiquement acceptables, formule (I) dans laquelle R1a, R1b, R1c, X, et Y sont définis dans la description. La présente invention porte également sur des compositions contenant lesdits composés qui sont utiles pour inhiber des kinases telles que Cdc7 et sur des procédés de traitement de maladies telles que le cancer.
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