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1. WO2011008896 - THERAPEUTIC METHODS USING CONTROLLED DELIVERY DEVICES HAVING ZERO ORDER KINETICS

Publication Number WO/2011/008896
Publication Date 20.01.2011
International Application No. PCT/US2010/042029
International Filing Date 14.07.2010
IPC
A61M 31/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
31Devices for introducing or retaining media, e.g. remedies, in cavities of the body
A61M 37/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
37Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
A61F 2/88 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
2Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
86Stents in a form characterised by wire-like elements; Stents in a form characterised by a net-like or mesh-like structure
88the wire-like elements formed as helical or spiral coils
A61L 27/14 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
14Macromolecular materials
CPC
A61B 17/06166
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
17Surgical instruments, devices or methods, e.g. tourniquets
04for suturing wounds; Holders or packages for needles or suture materials
06Needles ; ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
06166Sutures
A61B 2560/0219
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
2560Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
02Operational features
0204of power management
0214of power generation or supply
0219of externally powered implanted units
A61B 5/076
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Detecting, measuring or recording for diagnostic purposes
07Endoradiosondes
076Permanent implantations
A61B 5/4839
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Detecting, measuring or recording for diagnostic purposes
48Other medical applications
4836Diagnosis combined with treatment in closed-loop systems or methods
4839combined with drug delivery
A61B 5/686
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Detecting, measuring or recording for diagnostic purposes
68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
6846specially adapted to be brought in contact with an internal body part, i.e. invasive
6847mounted on an invasive device
686Permanently implanted devices, e.g. pacemakers, other stimulators, biochips
A61B 90/30
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
90Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
30Devices for illuminating a surgical field, the devices having an interrelation with other surgical devices or with a surgical procedure
Applicants
  • BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM [US]/[US] (AllExceptUS)
  • STAVCHANSKY, Salomon [US]/[US] (UsOnly)
  • HO, Paul, S. [US]/[US] (UsOnly)
  • BOWMAN, Phillip [US]/[US] (UsOnly)
  • LUO, Zhiquan [CN]/[US] (UsOnly)
  • WU, Zhuojie [CN]/[US] (UsOnly)
  • RASTOGI, Ashish [IN]/[US] (UsOnly)
Inventors
  • STAVCHANSKY, Salomon
  • HO, Paul, S.
  • BOWMAN, Phillip
  • LUO, Zhiquan
  • WU, Zhuojie
  • RASTOGI, Ashish
Agents
  • FLORES, Edwin, S.
Priority Data
61/225,30914.07.2009US
61/225,35214.07.2009US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) THERAPEUTIC METHODS USING CONTROLLED DELIVERY DEVICES HAVING ZERO ORDER KINETICS
(FR) MÉTHODES THÉRAPEUTIQUES UTILISANT DES DISPOSITIFS D'ADMINISTRATION CONTRÔLÉE AVEC UNE CINÉTIQUE D'ORDRE ZÉRO
Abstract
(EN)
An injectable or implantable medical device having orifice(s) on the surface that release an active agent with zero-order release kinetics is described herein. The device is a hollow matrix of any size or shape, which can be made from both metal and non-metal surfaces. The device comprises of a reservoir capable of releasing at least one therapeutic, diagnostic, or prophylactic agent via the orifices to the desired anatomical site. The developed device, due to its composite structure, has the ability to combine several release mechanisms, leading to zero-order release kinetics for most of the time. The composition provides zero-order kinetics, in part, because the diffusion rate of the drug from the device is slow which enables sink conditions. Hence, no back transfer or build up of drug occurs at anytime. Polymers are not required for controlled release.
(FR)
La présente invention concerne un dispositif médical injectable ou implantable, doté d'un ou de plusieurs orifices situés sur la surface qui libèrent un agent actif avec une cinétique de libération d'ordre zéro. Ledit dispositif est une matrice creuse de n'importe quelle taille ou n'importe quelle forme, qui peut être faite à partir de surfaces à la fois métalliques et non métalliques. Ce dispositif comprend un réservoir capable de libérer au moins un agent thérapeutique, diagnostique ou prophylactique via les orifices jusqu'au site anatomique désiré. Le dispositif mis au point, en raison de sa structure composite, possède la capacité de combiner plusieurs mécanismes de libération, débouchant sur une cinétique de libération d'ordre zéro la plupart du temps. La composition procure une cinétique d'ordre zéro, en partie car la vitesse de diffusion du médicament provenant du dispositif est lente, ce qui permet des conditions de puits. Ainsi, aucun rétrotransfert ni aucune accumulation de médicament ne se produit à aucun moment. Des polymères ne sont pas requis pour la libération contrôlée.
Also published as
Latest bibliographic data on file with the International Bureau