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1. (WO2011008809) CRYSTALLINE FREEBASE FORMS OF A BIPHENYL COMPOUND
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2011/008809 International Application No.: PCT/US2010/041903
Publication Date: 20.01.2011 International Filing Date: 14.07.2010
IPC:
A61K 31/445 (2006.01) ,C07D 401/12 (2006.01) ,A61P 11/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
445
Non-condensed piperidines, e.g. piperocaine
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
Applicants:
WOOLLAM, Grahame [GB/GB]; GB (UsOnly)
THERAVANCE, INC. [US/US]; 901 Gateway Boulevard South San Francisco, California 94080, US (AllExceptUS)
Inventors:
WOOLLAM, Grahame; GB
Agent:
HAGENAH, Jeffrey A.; Theravance, Inc. 901 Gateway Boulevard South San Francisco, California 94080, US
Priority Data:
61/225,80315.07.2009US
Title (EN) CRYSTALLINE FREEBASE FORMS OF A BIPHENYL COMPOUND
(FR) FORMES À BASE LIBRE CRISTALLINE D'UN COMPOSÉ BIPHENYLE
Abstract:
(EN) The invention provides two crystalline freebase forms of biphenyl-2-ylcarbamic acid l-(2-{[4-(4-carbamoylpiperidin-l-yImethyl)benzoyl]methylamino}ethyl)piperidin-4- yl ester. The invention also provides pharmaceutical compositions comprising the crystalline freebase or prepared using the crystalline freebases; processes and intermediates for preparing the crystalline freebases; and methods of using the crystalline freebases to treat a pulmonary disorder.
(FR) L'invention concerne deux formes à base libre cristalline d'acide biphényl-2-ylcarbamique de l-(2-{[4-(4-carbamoylpipéridin-l-yIméthyl)benzoyl]méthylamino}éthyle)pipéridin-4-yl ester. L'invention concerne également des compositions pharmaceutiques contenant ces bases libres cristallines ou préparées au moyen de celles-ci; des procédés et des intermédiaires pour la préparation des bases libres cristallines; ainsi que des méthodes d'utilisation de ces bases libres cristallines dans le traitement d'un trouble pulmonaire.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)