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1. WO2011008585 - METHODS AND COMPOSITIONS FOR PROTECTING AND TREATING NEUROINJURY

Publication Number WO/2011/008585
Publication Date 20.01.2011
International Application No. PCT/US2010/040903
International Filing Date 02.07.2010
IPC
A61K 31/045 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
A61K 31/215 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
A61K 31/335 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
A61K 31/38 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
38having sulfur as a ring hetero atom
A61P 25/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
CPC
A61K 31/047
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
047having two or more hydroxy groups, e.g. sorbitol
A61K 31/215
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
A61K 31/335
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
A61K 31/38
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
38having sulfur as a ring hetero atom
Applicants
  • MOREHOUSE SCHOOL MEDICINE [US]/[US] (AllExceptUS)
  • FORD, Byron, D. [US]/[US] (UsOnly)
  • FERCHMIN, Pedro, A. [US]/[US] (UsOnly)
  • ETEROVIC, Vesna, A. [US]/[US] (UsOnly)
Inventors
  • FORD, Byron, D.
  • FERCHMIN, Pedro, A.
  • ETEROVIC, Vesna, A.
Agents
  • WANG, Ping M. D.
Priority Data
12/829,05601.07.2010US
61/225,34114.07.2009US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS AND COMPOSITIONS FOR PROTECTING AND TREATING NEUROINJURY
(FR) PROCÉDÉS ET COMPOSITIONS POUR LA PROTECTION ET LE TRAITEMENT D'UNE LÉSION NEUROLOGIQUE
Abstract
(EN)
A method and composition for protecting and/or treating neuroinjury are disclosed. In one aspect, the present application discloses a method for protecting and/or treating a subject from organophosphate-induced neuronal injury. The method comprises administering to a subject an effective amount of 4R cembranoid, 4S cembranoid or a cembranoid analogue. In another aspect, the application discloses neuroprotective pharmaceutical compositions for protecting and/or treating a subject from organophosphate-induced neuronal injury. A kit for protecting and treating a subject from organophosphate-induced neurodamage is also disclosed.
(FR)
L'invention concerne un procédé et une composition pour protéger et/ou traiter une lésion neurologique. Selon un aspect, la présente demande décrit un procédé pour protéger et/ou traiter un sujet contre une lésion neurologique induite par l'organophosphate. Le procédé comprend l'administration à un sujet d'une quantité efficace de cembranoïde 4R, de cembranoïde 4S ou d'un analogue des cembranoïdes. Selon un autre aspect, la demande décrit des compositions pharmaceutiques neuroprotectrices pour protéger et/ou traiter un sujet contre une lésion neurologique induite par l'organophosphate. Une trousse de protection et de traitement d'un sujet contre les dommages neurologiques induits par l'organophosphate est également décrite.
Also published as
Latest bibliographic data on file with the International Bureau