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1. WO2011008495 - ARGINASE FORMULATIONS AND METHODS

Publication Number WO/2011/008495
Publication Date 20.01.2011
International Application No. PCT/US2010/040205
International Filing Date 28.06.2010
IPC
C12N 9/96 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
96Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
C12N 9/78 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14Hydrolases (3.)
78acting on carbon to nitrogen bonds other than peptide bonds (3.5)
A61K 38/50 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
46Hydrolases (3)
50acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
CPC
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C12N 9/78
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes; Proenzymes; Compositions thereof
14Hydrolases (3)
78acting on carbon to nitrogen bonds other than peptide bonds (3.5)
C12Y 305/03001
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
YENZYMES
305Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
03in linear amidines (3.5.3)
03001Arginase (3.5.3.1)
Applicants
  • THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM [US]/[US] (AllExceptUS)
  • GEORGIOU, George [US]/[US] (UsOnly)
  • STONE, Everett [US]/[US] (UsOnly)
Inventors
  • GEORGIOU, George
  • STONE, Everett
Agents
  • PARKER, David, L.
Priority Data
61/221,39629.06.2009US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ARGINASE FORMULATIONS AND METHODS
(FR) FORMULATIONS D'ARGINASE ET PROCÉDÉS
Abstract
(EN)
Methods and composition for generation of arginase variants with high serum persistence are provided. For example, in certain aspects methods for purifying pegylated arginase are described. Furthermore, the invention provides stabilized arginase multimers or pharmaceutical composition thereof.
(FR)
L'invention porte sur des procédés et une composition pour la génération de variants d'arginase avec une persistance élevée dans le sérum. Par exemple, sous certains aspects, l'invention porte sur des procédés de purification d'une arginase pegylée. De plus, l'invention fournit des multimères d'arginase stabilisés ou une composition pharmaceutique de ceux-ci.
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