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1. WO2011008053 - PROPIONATE OF N,N-DIMETHYL IMIDOCARBON IMIDIC DIAMIDE, METHOD OF PREPARING SAME, AND PHARMACEUTICAL COMPOSITIONS AND COMBINATIONS CONTAINING SAME

Publication Number WO/2011/008053
Publication Date 20.01.2011
International Application No. PCT/KR2010/004673
International Filing Date 16.07.2010
IPC
C07C 279/26 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
279Derivatives of guanidine, i.e. compounds containing the group the singly-bound nitrogen atoms not being part of nitro or nitroso groups
20containing any of the groups X being a hetero atom, Y being any atom, e.g. acylguanidines
24Y being a hetero atom
26X and Y being nitrogen atoms, i.e. biguanides
C07C 277/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
277Preparation of guanidine or its derivatives, i.e. compounds containing the group the singly-bound nitrogen atoms not being part of nitro or nitroso groups
C07C 53/122 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
53Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
122Propionic acid
CPC
A61P 3/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
C07C 277/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
277Preparation of guanidine or its derivatives, i.e. compounds containing the group , the singly-bound nitrogen atoms not being part of nitro or nitroso groups
C07C 279/26
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
279Derivatives of guanidine, i.e. compounds containing the group , the singly-bound nitrogen atoms not being part of nitro or nitroso groups
20containing any of the groups , X being a hetero atom, Y being any atom, e.g. acylguanidines
24Y being a hetero atom
26X and Y being nitrogen atoms, i.e. biguanides
C07C 53/122
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
53Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
122Propionic acid
Applicants
  • 한올바이오파마주식회사 HANALL BIOPHARMA CO., LTD. [KR]/[KR] (AllExceptUS)
  • 김성욱 KIM, Sung Wuk [KR]/[KR] (UsOnly)
  • 전성수 JUN, Sung Soo [KR]/[KR] (UsOnly)
  • 민창희 MIN, Changhee [KR]/[KR] (UsOnly)
  • 강민석 KANG, Min Seok [KR]/[KR] (UsOnly)
  • 김용은 KIM, Yong Eun [KR]/[KR] (UsOnly)
  • 구자성 KOO, Ja Seong [KR]/[KR] (UsOnly)
Inventors
  • 김성욱 KIM, Sung Wuk
  • 전성수 JUN, Sung Soo
  • 민창희 MIN, Changhee
  • 강민석 KANG, Min Seok
  • 김용은 KIM, Yong Eun
  • 구자성 KOO, Ja Seong
Agents
  • 안소영 AHN, So-Young
Priority Data
10-2009-006524417.07.2009KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) PROPIONATE OF N,N-DIMETHYL IMIDOCARBON IMIDIC DIAMIDE, METHOD OF PREPARING SAME, AND PHARMACEUTICAL COMPOSITIONS AND COMBINATIONS CONTAINING SAME
(FR) PROPIONATE DE N,N-DIMÉTHYL DIAMIDE IMIDOCARBONIMIDIQUE, SON PROCÉDÉ DE PRÉPARATION AINSI QUE COMPOSITIONS ET COMBINAISONS PHARMACEUTIQUES LE CONTENANT
(KO) N,N-디메틸 이미도디카르본이미딕 디아미드의 프로피온산염, 이의 제조방법, 이를 포함하는 약제학적 조성물 및 이를 포함하는 복합제제
Abstract
(EN)
The present invention provides metformin propionate, a method of preparing the same, and pharmaceutical compositions and combinations containing the same. The metformin propionate according to the present invention has an excellent pharmacological effect as compared with metformin hydrochloride and is capable of achieving a therapeutic purpose by administering an amount less than metformin hydrochloride. Furthermore, the metformin propionate has excellent physicochemical properties, such as solubility, stability, hygroscopicity and adsorption preventing property, in processibility of formulations and thereby is capable of being usefully utilized as a pharmaceutically acceptable salt of the metformin.
(FR)
La présente invention concerne du propionate de metformine, un procédé de préparation de ce dernier, ainsi que des compositions et des combinaisons pharmaceutiques le contenant. Le propionate de metformine selon la présente invention présente un excellent effet pharmacologique comparé à l'hydrochlorure de metformine et permet d'obtenir un effet thérapeutique par administration d'une quantité inférieure à celle de l'hydrochlorure de metformine. En outre, le propionate de metformine présente d'excellentes propriétés physico-chimiques, telles qu'une solubilité, une stabilité, une hygroscopicité et une propriété de prévention d'adsorption, utilisées pour le traitement de formulations et peut par conséquent être efficacement utilisée en tant que sel pharmaceutiquement acceptable de la metformine.
(KO)
본 발명은 메트포르민 프로피온산염, 이의 제조방법, 이를 포함하는 약제학적 조성물 및 복합제제를 제공한다. 본 발명의 메트포르민 프로피온산염은 메트포르민 염산염에 비해 약리학적 효과가 우수할 뿐만 아니라 메트포르민 염산염보다 적은 용량을 투여하여 치료 목적을 달성할 수 있다. 또한 용해도, 안정성, 흡습성, 부착방지특성 같은 제형으로서의 가공성 등의 물리화학적 성질이 우수하여 메트포르민의 약제학적으로 허용되는 염으로써 유용하게 이용될 수 있다.
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