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1. WO2011007612 - ANTI-INFLAMMATORY AGENT FOR ORAL APPLICATION, AND ANTI-INFLAMMATORY PEPTIDE FOR ORAL APPLICATION

Publication Number WO/2011/007612
Publication Date 20.01.2011
International Application No. PCT/JP2010/057993
International Filing Date 12.05.2010
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 1/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 1/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
12Antidiarrhoeals
A61P 29/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A61P 43/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
C07K 5/087 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
08Tripeptides
087the side chain of the first amino acid containing carbocyclic rings, e.g. Phe, Tyr
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A61P 1/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
12Antidiarrhoeals
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applicants
  • 不二製油株式会社 FUJI OIL COMPANY LIMITED [JP]/[JP] (AllExceptUS)
  • 伊吹 昌久 IBUKI Masahisa [JP]/[JP] (UsOnly)
  • 長谷川 芳則 HASEGAWA Yoshinori [JP]/[JP] (UsOnly)
  • 峯 芳徳 MINE Yoshinori [JP]/[CA]
Inventors
  • 伊吹 昌久 IBUKI Masahisa
  • 長谷川 芳則 HASEGAWA Yoshinori
  • 峯 芳徳 MINE Yoshinori
Priority Data
2009-16432113.07.2009JP
2009-16432313.07.2009JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) ANTI-INFLAMMATORY AGENT FOR ORAL APPLICATION, AND ANTI-INFLAMMATORY PEPTIDE FOR ORAL APPLICATION
(FR) AGENT ANTI-INFLAMMATOIRE POUR APPLICATION ORALE, ET PEPTIDE ANTI-INFLAMMATOIRE POUR APPLICATION ORALE
(JA) 経口性抗炎症剤及び経口性抗炎症ペプチド
Abstract
(EN)
Disclosed are a composition having an anti-inflammatory function and a therapeutic method using the composition, both of which are effective for inflammatory diseases such as inflammatory bowel disease. Specifically disclosed are: an anti-inflammatory functional agent for oral application, which comprises a soybean peptide, wherein the soybean peptide contains fractions each having a molecular weight of 500 or less and excluding any free amino acid in an amount of 40 wt% or more and has a free amino acid content of 7 wt% or less; and a therapeutic method using the anti-inflammatory functional agent. More specifically disclosed are: a novel tripeptide which comprises the following amino acid sequence: phenylalanine-leucine-valine or valine-proline-tyrosine and has an anti-inflammatory function; an anti-inflammatory composition for oral application, a medicinal agent and a feed, each of which contains the novel tripeptide as an active ingredient; and a method for treating inflammatory bowel disease using the novel peptide.
(FR)
L'invention porte sur une composition ayant une fonction anti-inflammatoire et sur un procédé thérapeutique utilisant la composition, tous deux étant efficaces pour des maladies inflammatoires, telle qu'une maladie intestinale inflammatoire. De façon spécifique, l'invention porte sur : un agent fonctionnel anti-inflammatoire pour application orale, qui comprend un peptide de soja, le peptide de soja contenant des fractions ayant chacune une masse moléculaire de 500 ou moins, et excluant tout acide aminé libre dans une quantité de 40 % en poids ou plus, et ayant une teneur en acide aminé libre de 7 % en poids ou moins ; et un procédé thérapeutique utilisant l'agent fonctionnel anti-inflammatoire. De façon plus spécifique, l'invention porte sur : un nouveau tripeptide qui comprend la séquence d'acides aminés suivante : phénylalanine-leucine-valine ou valine-proline-tyrosine, et a une fonction anti-inflammatoire ; une composition anti-inflammatoire pour application orale, un agent médicinal et une charge, chacun d'eux contenant le nouveau tripeptide comme ingrédient actif ; et un procédé de traitement d'une maladie intestinale inflammatoire à l'aide du nouveau peptide.
(JA)
本発明の目的は、炎症性腸管疾患等の炎症性疾患に効果がある、抗炎症機能を有する組成物や当該組成物を使用した治療方法の提供にある 。 本発明は、遊離アミノ酸を除く分子量500以下の画分が40重量%以上でありかつ、遊離アミノ酸含量が7重量%以下である、大豆ペプチドである経口性抗炎症機能剤および、それを用いた治療法である。そして本発明はフェニルアラニン-ロイシン-バリンもしくはバリンープロリンーチロシンのアミノ酸配列からなる抗炎症機能をもつ新規トリペプチドであって、それらを有効成分とする、経口性抗炎症組成物、医薬品、飼料であり、かつ、それら新規ペプチドを用いた炎症性腸疾患の治療法に関するものである。
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