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1. WO2011006985 - NEUROTENSIN ANALOGUES FOR RADIOISOTOPE TARGETING TO NEUROTENSIN RECEPTOR-POSITIVE TUMORS

Publication Number WO/2011/006985
Publication Date 20.01.2011
International Application No. PCT/EP2010/060293
International Filing Date 16.07.2010
IPC
C07K 7/08 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
08having 12 to 20 amino acids
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 51/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51Preparations containing radioactive substances for use in therapy or testing in vivo
02characterised by the carrier ; , i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
04Organic compounds
08Peptides, e.g. proteins ; , carriers being peptides, polyamino acids, proteins
A61K 51/085
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51Preparations containing radioactive substances for use in therapy or testing in vivo
02characterised by the carrier ; , i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
04Organic compounds
08Peptides, e.g. proteins ; , carriers being peptides, polyamino acids, proteins
085the peptide being neurotensin
A61K 51/088
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51Preparations containing radioactive substances for use in therapy or testing in vivo
02characterised by the carrier ; , i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
04Organic compounds
08Peptides, e.g. proteins ; , carriers being peptides, polyamino acids, proteins
088conjugates with carriers being peptides, polyamino acids, proteins
C07K 7/083
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
08having 12 to 20 amino acids
083Neurotensin
Applicants
  • INSERM (Institut National de la Santé et de la Recherche Médicale) [FR]/[FR] (AllExceptUS)
  • GRUAZ-GUYON, Anne [FR]/[FR] (UsOnly)
  • PELAPRAT, Didier [FR]/[FR] (UsOnly)
  • BARBET, Jacques [FR]/[FR] (UsOnly)
  • TOURWE, Dirk [BE]/[BE] (UsOnly)
Inventors
  • GRUAZ-GUYON, Anne
  • PELAPRAT, Didier
  • BARBET, Jacques
  • TOURWE, Dirk
Agents
  • BERNARDI, Céline
Priority Data
09305679.416.07.2009EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NEUROTENSIN ANALOGUES FOR RADIOISOTOPE TARGETING TO NEUROTENSIN RECEPTOR-POSITIVE TUMORS
(FR) ANALOGUES DE LA NEUROTENSINE POUR LE CIBLAGE PAR RADIO-ISOTOPE DE TUMEURS POSITIVES AUX RÉCEPTEURS DE LA NEUROTENSINE
Abstract
(EN)
The invention relates to a new neurotensin analogue, or a salt thereof, useful for targeting to neurotensin receptor-positive tumors, like ductal pancreatic adenocarcinoma, exocrine pancreatic cancer, invasive ductal breast cancers, colon adenocarcinoma, small cell lung carcinoma, Ewing sarcoma, meningioma, medulloblastoma and astrocytoma.
(FR)
Cette invention concerne un nouvel analogue de la neurotensine, ou son sel, utilisé pour cibler les tumeurs positives aux récepteurs de la neurotensine, comme l'adénocarcinome canalaire du pancréas, le cancer du pancréas exocrine, les cancers du sein canalaires invasifs, l'adénocarcinome du côlon, le cancer du poumon à petites cellules, le sarcome d'Ewing, le méningiome, le médulloblastome et l'astrocytome.
Also published as
Latest bibliographic data on file with the International Bureau