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1. WO2011006794 - 3-OXO-2, 3-DIHYDRO-1H-ISOINDOLE-4-CARBOXAMIDES AS PARP INHIBITORS

Publication Number WO/2011/006794
Publication Date 20.01.2011
International Application No. PCT/EP2010/059607
International Filing Date 06.07.2010
IPC
C07D 209/46 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
209Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02condensed with one carbocyclic ring
44Iso-indoles; Hydrogenated iso-indoles
46with an oxygen atom in position 1
C07D 401/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
C07D 401/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
C07D 405/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14containing three or more hetero rings
C07D 409/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
409Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
14containing three or more hetero rings
C07D 417/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
14containing three or more hetero rings
CPC
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
A61P 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
C07D 209/46
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
209Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02condensed with one carbocyclic ring
44Iso-indoles; Hydrogenated iso-indoles
46with an oxygen atom in position 1
Applicants
  • NERVIANO MEDICAL SCIENCES S.r.l. [IT]/[IT] (AllExceptUS)
  • PAPEO, Gianluca Mariano Enrico [IT]/[IT] (UsOnly)
  • ANATOLIEVNA BUSEL, Alina [RU]/[RU] (UsOnly)
  • KHVAT, Alexander [US]/[US] (UsOnly)
  • KRASAVIN, Mikhail Yurievitch [RU]/[RU] (UsOnly)
  • FORTE, Barbara [IT]/[IT] (UsOnly)
  • ZUCCOTTO, Fabio [IT]/[IT] (UsOnly)
Inventors
  • PAPEO, Gianluca Mariano Enrico
  • ANATOLIEVNA BUSEL, Alina
  • KHVAT, Alexander
  • KRASAVIN, Mikhail Yurievitch
  • FORTE, Barbara
  • ZUCCOTTO, Fabio
Common Representative
  • NERVIANO MEDICAL SCIENCES S.r.l.
Priority Data
09165443.414.07.2009EP
10159776.313.04.2010EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) 3-OXO-2, 3-DIHYDRO-1H-ISOINDOLE-4-CARBOXAMIDES AS PARP INHIBITORS
(FR) 3-OXO-2,3-DIHYDRO-1H-ISOINDOLE-4-CARBOXAMIDES EN TANT QU'INHIBITEURS DE PARP
Abstract
(EN)
There are provided substituted 3-oxo -2, 3 -dihydro-1H-isoindole-4-carboxamide derivatives (I) which selectively inhibit the activity of poly (ADP-ribose) polymerase PARP-1 with respect to poly (ADP-ribose) polymerase PARP-2. The compounds of this invention are therefore useful in treating diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating, diseases utilizing pharmaceutical compositions comprising these compounds.
(FR)
L'invention porte sur des dérivés 3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide substitués (1) qui inhibent de façon sélective l'activité de la poly(ADP-ribose)polymérase PARP-1 par rapport à la poly(ADP-ribose)polymérase PARP-2. Les composés de cette invention sont donc utiles dans le traitement de maladies telles que le cancer, des maladies cardiovasculaires, des lésions du système nerveux central et différentes formes d'inflammation. La présente invention porte également sur des procédés de préparation de ces composés, sur des compositions pharmaceutiques comprenant ces composés et sur des procédés de traitement des maladies à l'aide de compositions pharmaceutiques comprenant ces composés.
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