Processing

Please wait...

Settings

Settings

Goto Application

1. WO2011006011 - THERANOSTIC POLYCATION BEACONS COMPRISING OLIGOETHYLENEAMINE REPEATING UNITS AND LANTHANIDE CHELATES

Publication Number WO/2011/006011
Publication Date 13.01.2011
International Application No. PCT/US2010/041432
International Filing Date 08.07.2010
IPC
C08G 69/44 2006.01
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
69Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
44Polyester-amides
C08G 73/16 2006.01
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
73Macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing nitrogen, with or without oxygen or carbon, not provided for in groups C08G12/-C08G71/238
06Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule; Polyhydrazides; Polyamide acids or similar polyimide precursors
10Polyimides; Polyester-imides; Polyamide-imides; Polyamide acids or similar polyimide precursors
16Polyester-imides
C12Q 1/68 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
G01N 33/68 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
G01N 24/08 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
24Investigating or analysing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
08by using nuclear magnetic resonance
CPC
A61K 49/0019
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
001Preparation for luminescence or biological staining
0013Luminescence
0017Fluorescence in vivo
0019characterised by the fluorescent group
A61K 49/0054
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
001Preparation for luminescence or biological staining
0013Luminescence
0017Fluorescence in vivo
005characterised by the carrier molecule carrying the fluorescent agent
0054Macromolecular compounds, i.e. oligomers, polymers, dendrimers
A61K 49/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
08characterised by the carrier
10Organic compounds
12Macromolecular compounds
A61P 31/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A61P 37/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
04Immunostimulants
C07C 237/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
237Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
02having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
04the carbon skeleton being acyclic and saturated
10having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
Applicants
  • VIRGINIA TECH INTELLECTUAL PROPERTIES INC. [US]/[US] (AllExceptUS)
  • REINEKE, Theresa [US]/[US] (UsOnly)
  • BRYSON, Joshua [US]/[US] (UsOnly)
Inventors
  • REINEKE, Theresa
  • BRYSON, Joshua
Agents
  • MAYBERRY, Michele
Priority Data
61/223,81208.07.2009US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) THERANOSTIC POLYCATION BEACONS COMPRISING OLIGOETHYLENEAMINE REPEATING UNITS AND LANTHANIDE CHELATES
(FR) BALISES POLYCATIONIQUES THÉRANOSTIQUES COMPRENANT DES MOTIFS RÉPÉTÉS D'OLIGOÉTHYLÈNEAMINE ET DES CHÉLATES DE LANTHANIDES
Abstract
(EN)
The present invention relates to vehicles for delivering macromolecules into cells. More particularly, embodiments of the invention relate to compounds and methods for binding and compacting nucleic acids into nanoparticles for transferring the polynucleotides into cells and which can be configured to provide a mechanism for visualization of the delivery vehicles on the nm/μm scale by microscopy and on the sub-mm scale by magnetic resonance imaging. Polycations according to embodiments of the invention have been designed to contain repeated oligoethyleneamines, for binding and compacting nucleic acids into nanoparticles, and lanthanide (Ln) chelates (for example, using luminescent europium Eu3+ and paramagnetic gadolinium Gd3+). Especially preferred, are structures chelated with either Eu3+ or Gd3+ for microscopy or MRI imaging, respectively. Such chelated lanthanides allow the visualization of the delivery vehicle both on the nm/μm scale by way of microscopy and on the sub-mm scale using MRI.
(FR)
La présente invention concerne des véhicules pour délivrer des macromolécules dans des cellules. Plus particulièrement, des modes de réalisation de la présente invention concernent des composés et des procédés pour lier et compacter des acides nucléiques en nanoparticules afin de transférer les polynucléotides dans des cellules et qui peuvent être conçus pour fournir un mécanisme de visualisation des véhicules de délivrance à l'échelle nm/µm par microscopie et à l'échelle inférieure au mm par imagerie par résonance magnétique. Les polycations selon des modes de réalisation de l'invention ont été conçus pour contenir des oligoéthylenèamines répétées permettant la liaison et le compactage d'acides nucléiques en nanoparticules, et des chélates de lanthanides (Ln) (par exemple, employant de l'europium Eu3+ luminescent et du gadolinium Gd3+ paramagnétique). Des structures particulièrement préférées sont des structures chélatées avec Eu3+ ou Gd3+ pour la microscopie ou l'imagerie IRM, respectivement. Ces lanthanides chélatés permettent la visualisation du véhicule de délivrance à l'échelle nm/µm au moyen de la microscopie et à l'échelle inférieure au mm au moyen de l'IRM.
Latest bibliographic data on file with the International Bureau