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1. WO2011005982 - BACTERIAL ADHERENCE AND ANTI-ADHERENCE TO MUCUS, EPITHELIAL CELLS AND OTHER CELLS

Publication Number WO/2011/005982
Publication Date 13.01.2011
International Application No. PCT/US2010/041396
International Filing Date 08.07.2010
IPC
C12Q 1/00 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
G01N 33/00 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
CPC
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C12Q 1/10
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
02involving viable microorganisms
04Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
10Enterobacteria
G01N 2333/245
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
195from bacteria
24from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
245Escherichia (G)
G01N 33/56916
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
56911Bacteria
56916Enterobacteria, e.g. shigella, salmonella, klebsiella, serratia
Applicants
  • ALLTECH, INC. [US]/[US] (AllExceptUS)
  • DAWSON, Karl, A. [US]/[US] (UsOnly)
  • MORAN, Colm [IE]/[FR] (UsOnly)
  • APAJALAHTI, Juha [FI]/[FI] (UsOnly)
  • LAURAEUS, Marko [FI]/[FI] (UsOnly)
Inventors
  • DAWSON, Karl, A.
  • MORAN, Colm
  • APAJALAHTI, Juha
  • LAURAEUS, Marko
Agents
  • SISK, Tyler, J.
Priority Data
61/223,75508.07.2009US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) BACTERIAL ADHERENCE AND ANTI-ADHERENCE TO MUCUS, EPITHELIAL CELLS AND OTHER CELLS
(FR) ADHÉRENCE ET ANTI-ADHÉRENCE BACTÉRIENNE AU MUCUS, AUX CELLULES ÉPITHÉLIALES ET AUTRES CELLULES
Abstract
(EN)
The present invention generally relates to methods for detecting, identifying, and measuring bacterial adherence to mucus and epithelial cells. In particular, the present invention provides assays for detecting and identifying the presence or absence of bacterial adherence to mucus (epithelial cells (e.g., present in the intestines), or other portion of an animal where bacteria may be present, and methods for identifying and characterizing (e.g., the efficacy of) modulators of bacterial adherence to mucus and epithelial cells, or other portion of the animal where bacteria may be present.
(FR)
La présente invention concerne d'une manière générale des procédés de détection, d'identification et de mesure de l'adhérence bactérienne au mucus et aux cellules épithéliales. En particulier, la présente invention porte sur des essais pour détecter et identifier la présence ou l'absence d'une adhérence bactérienne au mucus, aux cellules épithéliales (par exemple, présentes dans les intestins), ou autre partie d'un animal où des bactéries peuvent être présentes. L'invention porte également sur des procédés d'identification et de caractérisation (par exemple, de l'efficacité) de modulateurs de l'adhérence bactérienne au mucus et aux cellules épithéliales, ou autre partie de l'animal où des bactéries peuvent être présentes.
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