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1. WO2011004972 - PIPERAZINYL 3-AMINOPYRROLIDINE DERIVATIVES AS A CCR2 ANTAGONIST

Publication Number WO/2011/004972
Publication Date 13.01.2011
International Application No. PCT/KR2010/003790
International Filing Date 11.06.2010
IPC
C07D 403/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
C07D 403/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
C07D 207/273 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
207Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
18having one double bond between ring members or between a ring member and a non-ring member
22with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
24Oxygen or sulfur atoms
262-Pyrrolidones
273with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
CPC
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 11/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
02Nasal agents, e.g. decongestants
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
A61P 13/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
A61P 17/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
Applicants
  • 양지화학 주식회사 YANG JI CHEMICAL CO., LTD. [KR]/[KR] (AllExceptUS)
  • 임지웅 LIM, Jee Woong [KR]/[KR] (UsOnly)
  • 김종훈 KIM, Jong-Hoon [KR]/[KR] (UsOnly)
  • 옥민호 OAK, Min-Ho [KR]/[KR] (UsOnly)
  • 나용호 NA, Yongho [KR]/[KR] (UsOnly)
  • 오유나 OH, Youna [KR]/[KR] (UsOnly)
  • 강소희 KANG, So-Hee [KR]/[KR] (UsOnly)
  • 이정옥 LEE, Jung-Ok [KR]/[KR] (UsOnly)
  • 손정덕 SOHN, Jung-Duk [KR]/[KR] (UsOnly)
  • 이승우 LEE, Seung-Woo [KR]/[KR] (UsOnly)
Inventors
  • 임지웅 LIM, Jee Woong
  • 김종훈 KIM, Jong-Hoon
  • 옥민호 OAK, Min-Ho
  • 나용호 NA, Yongho
  • 오유나 OH, Youna
  • 강소희 KANG, So-Hee
  • 이정옥 LEE, Jung-Ok
  • 손정덕 SOHN, Jung-Duk
  • 이승우 LEE, Seung-Woo
Agents
  • 특허법인주원 B&IP-JOOWON PATENT AND LAW FIRM
Priority Data
10-2009-006313610.07.2009KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) PIPERAZINYL 3-AMINOPYRROLIDINE DERIVATIVES AS A CCR2 ANTAGONIST
(FR) DÉRIVÉS DE PIPÉRAZINYL 3-AMINOPYRROLIDINE EN TANT QU'ANTAGONISTE DU CCR2
(KO) CCR2 길항제로서의 피페라지닐에틸 3-아미노피롤리딘 유도체
Abstract
(EN)
The present invention relates to compounds of chemical formula 1, which exhibit antagonistic effects against chemokine receptor 2 (CCR2), and to salts or isomers thereof. The compounds are useful in treating, preventing, or improving rheumatoid arthritis, arteriosclerosis, multiple sclerosis, asthma and other CCR2-related diseases. R1, R2, R3, R4, R5, R6, R7, R8 and R9 in chemical formula 1 are identical to those expressed in the present specification.
(FR)
La présente invention concerne des composés de formule chimique 1, lesquels présentent des effets antagonistes sur le récepteur de chimiokine 2 (CCR2), et leurs sels ou isomères. Les composés sont utiles pour traiter, prévenir ou améliorer la polyarthrite rhumatoïde, l'artériosclérose, la sclérose en plaques, l'asthme et d'autres maladies associées au CCR2. R1, R2, R3, R4, R5, R6, R7, R8 et R9 dans la formule chimique 1 sont identiques à ceux décrits dans le présent mémoire.
(KO)
본 발명은 CCR2 (chemokine receptor 2) 길항 효과를 나타내는 화학식 1의 화합물, 이것의 염 또는 이성질체에 관한 것으로서, 이러한 화합물은 류마티스 관절염, 동맥경화증, 다발성경화증, 천식 및 기타 CCR2에 관련된 여러 질환을 치료, 예방 또는 개선하는 데 유용하다. 화학식 1에서 R1, R2, R3, R4, R5, R6, R7, R8 및 R9는 본 명세서에서 정의된 바와 같다.
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