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1. WO2011004192 - ANIMAL MODELS AND THERAPEUTIC MOLECULES

Publication Number WO/2011/004192
Publication Date 13.01.2011
International Application No. PCT/GB2010/051122
International Filing Date 07.07.2010
Chapter 2 Demand Filed 11.02.2011
IPC
A01K 67/027 2006.01
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67Rearing or breeding animals, not otherwise provided for; New breeds of animals
027New breeds of vertebrates
C07K 16/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
C07K 16/46 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46Hybrid immunoglobulins
C12N 15/85 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
CPC
A01K 2207/15
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2207Modified animals
15Humanized animals
A01K 2217/05
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2217Genetically modified animals
05Animals comprising random inserted nucleic acids (transgenic)
A01K 2217/052
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2217Genetically modified animals
05Animals comprising random inserted nucleic acids (transgenic)
052inducing gain of function
A01K 2217/072
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2217Genetically modified animals
07Animals genetically altered by homologous recombination
072maintaining or altering function, i.e. knock in
A01K 2227/105
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2227Animals characterised by species
10Mammal
105Murine
A01K 2267/01
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2267Animals characterised by purpose
01Animal expressing industrially exogenous proteins
Applicants
  • KYMAB LIMITED [GB]/[GB] (AllExceptUS)
  • BRADLEY, Allan [GB]/[GB] (UsOnly)
  • LEE, E-Chiang [US]/[GB] (UsOnly)
  • LIANG, Qi [CN]/[GB] (UsOnly)
  • WANG, Wei [CN]/[GB] (UsOnly)
Inventors
  • BRADLEY, Allan
  • LEE, E-Chiang
  • LIANG, Qi
  • WANG, Wei
Agents
  • OLSWANG LLP
Priority Data
0911846.408.07.2009GB
0913102.028.07.2009GB
61/223,96008.07.2009US
61/355,66617.06.2010US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ANIMAL MODELS AND THERAPEUTIC MOLECULES
(FR) MODÈLES D'ANIMAUX ET MOLÉCULES THÉRAPEUTIQUES
Abstract
(EN)
The invention discloses methods for the generation of chimaeric human –non human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced,and derivatives thereofincluding fully humanised antibodies;compositions comprising said antibodies, antibody chainsand derivatives, as well as cells, non-human mammals and vectors, suitablefor use in said methods.
(FR)
L'invention porte sur des procédés pour la génération d'anticorps humains chimériques – non humains et de chaînes d'anticorps chimériques, sur des anticorps et des chaînes d'anticorps ainsi produits, et sur des dérivés de ceux-ci, comprenant des anticorps totalement humanisés; sur des compositions comprenant lesdits anticorps, lesdites chaînes d'anticorps et sur des dérivés, ainsi que sur des cellules, sur des mammifères non humains et sur des vecteurs, appropriés pour être utilisés dans lesdits procédés.
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