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1. WO2011004175 - VISCOUS TOPICAL ANTIMICROBIAL COMPOSITIONS

Publication Number WO/2011/004175
Publication Date 13.01.2011
International Application No. PCT/GB2010/051027
International Filing Date 22.06.2010
IPC
A61K 8/35 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
33containing oxygen
35Ketones, e.g. quinones, benzophenone
A61K 8/39 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
33containing oxygen
39Derivatives containing from 2 to 10 oxyalkylene groups
A61K 8/42 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
40containing nitrogen
42Amides
A61K 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61K 31/205 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
205Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
A61Q 17/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
17Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
04Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
CPC
A61K 31/205
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
205Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
A61K 8/35
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
33containing oxygen
35Ketones, e.g. benzophenone
A61K 8/42
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
40containing nitrogen
42Amides
A61K 8/86
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
72containing organic macromolecular compounds
84obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
86Polyethers
A61K 9/0014
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0014Skin, i.e. galenical aspects of topical compositions
A61Q 17/005
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
17Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
005Antimicrobial preparations
Applicants
  • RECKITT & COLMAN (OVERSEAS) LIMITED [GB]/[GB] (AllExceptUS)
  • BURT, Willard [US]/[US] (UsOnly)
  • CLAYTON, James Steven [US]/[US] (UsOnly)
  • KOSTURKO, Richard John [US]/[US] (UsOnly)
Inventors
  • BURT, Willard
  • CLAYTON, James Steven
  • KOSTURKO, Richard John
Agents
  • CAWDELL, Karen
Priority Data
0911951.209.07.2009GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) VISCOUS TOPICAL ANTIMICROBIAL COMPOSITIONS
(FR) COMPOSITIONS ANTIMICROBIENNES TOPIQUES VISQUEUSES
Abstract
(EN)
Provided are antimicrobial compositions especially suited for application to the epidermis, e.g., hands, arms, legs, face, scalp as well as other body areas which preferably exhibits an acidic pH. The compositions exhibit at least 3 log kill efficacy, preferably at least 4 log kill efficacy at 60 seconds contact time of at least two, preferably at least three and most preferably at least four of microorganisms selected from the group consisting of: S. aureus, E. coli, P. aeruginosa and E.hirae, according to the protocols of prEN 12054. The compositions are largely aqueous and desirably exhibit a viscosity of at least 500 cPs at 25°C, and desirably exhibit a pH of 4.5-5.5. Methods for the manufacture of the topical antimicrobial compositions and methods for their use are also disclosed. The antimicrobial compositions also find utility in the treatment of inanimate hard surfaces and inanimate soft surfaces.
(FR)
L'invention concerne des compositions antimicrobiennes se prêtant particulièrement à une application sur l'épiderme, par exemple sur les mains, les bras, les jambes, le visage, le cuir chevelu, et d'autres parties du corps qui présentent de préférence un pH acide. Les compositions présentent un taux de destruction d'au moins 3 log, de préférence un taux de destruction d'au moins 4 log à un temps de contact de 60 secondes d'au moins deux, de préférence d'au moins trois et idéalement d'au moins quatre microorganismes choisis dans le groupe constitué par : S. aureus, E. coli, P. aeruginosa et E.hirae, selon les protocoles de la technique connue EN 12054. Les compositions sont largement aqueuses et présentent, de préférence, une viscosité d'au moins 500 cPs à 25° C, et un pH de 4,5-5,5. L'invention porte également sur des procédés de fabrication des compositions antimicrobiennes topiques et sur des procédés pour leur utilisation. En outre, ces compositions sont utiles dans le traitement de surfaces dures et molles inanimées.
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