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1. WO2011003999 - METALLIC NANOPARTICLES, PREPARATION AND USES THEREOF

Publication Number WO/2011/003999
Publication Date 13.01.2011
International Application No. PCT/EP2010/059871
International Filing Date 09.07.2010
IPC
A61K 41/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
41Medicinal preparations obtained by treating materials with wave energy or particle radiation
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61K 41/0038
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
41Medicinal preparations obtained by treating materials with wave energy or particle radiation ; ; Therapies using these preparations
0038Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
A61N 2005/1098
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
5Radiation therapy
10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
1092Details
1098Enhancing the effect of the particle by an injected agent or implanted device
A61N 5/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
5Radiation therapy
10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applicants
  • NANOBIOTIX [FR]/[FR] (AllExceptUS)
  • LEVY, Laurent [FR]/[FR] (UsOnly)
  • POTTIER, Agnès [FR]/[FR] (UsOnly)
  • POUL, Laurence [FR]/[FR] (UsOnly)
  • MAGGIORELLA, Laurence [FR]/[FR] (UsOnly)
Inventors
  • LEVY, Laurent
  • POTTIER, Agnès
  • POUL, Laurence
  • MAGGIORELLA, Laurence
Agents
  • STARCK-LOUDES, Anne-Caroline
Priority Data
09165157.010.07.2009EP
61/224,57610.07.2009US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METALLIC NANOPARTICLES, PREPARATION AND USES THEREOF
(FR) NANOPARTICULES MÉTALLIQUES, LEUR PRÉPARATION ET LEURS UTILISATIONS
Abstract
(EN)
The present application relates to activable nanoparticles which can be used in the health sector, in particular in human health, to disturb, alter or destroy target cells, tissues or organs. It more particularly relates to nanoparticles which can generate a significantly efficient therapeutic effect, when exposed to ionizing radiations. The inventive nanoparticle is a metallic nanoparticle having, as the largest size, a size comprised between about 80 and 105 nm, the metal having preferably an atomic number (Z) of at least 25. The invention also relates to pharmaceutical compositions comprising a population of nanoparticles as defined previously, as well as to their uses.
(FR)
La présente invention concerne des nanoparticules activables pouvant être utilisées dans le secteur de la santé, en particulier de la santé humaine, pour perturber, modifier ou détruire des cellules, des tissus ou des organes cibles. Elle concerne plus particulièrement des nanoparticules pouvant générer un effet thérapeutique significativement efficace, lorsqu'elles sont exposées à des radiations ionisantes. La nanoparticule de l'invention est une nanoparticule métallique ayant, comme dimension la plus grande, une taille comprise entre environ 80 et 105 nm, le métal ayant de préférence un numéro atomique (Z) d'au moins 25. L'invention concerne également des compositions pharmaceutiques contenant une population de nanoparticules telles que définies précédemment, ainsi que leurs utilisations.
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