Processing

Please wait...

PATENTSCOPE will be unavailable a few hours for maintenance reason on Saturday 31.10.2020 at 7:00 AM CET
Settings

Settings

Goto Application

1. WO2011003357 - NUCLEAR MAGNETIC RESONANCE CONTRAST AGENT FOR LIVER OR SPLEEN AND PREPARATION METHOD THEREOF

Publication Number WO/2011/003357
Publication Date 13.01.2011
International Application No. PCT/CN2010/075066
International Filing Date 08.07.2010
IPC
A61K 49/08 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations
08characterised by the carrier
CPC
A61K 49/1881
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
18characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
1818particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
1821coated or functionalised microparticles or nanoparticles
1824coated or functionalised nanoparticles
1878the nanoparticle having a magnetically inert core and a (super)(para)magnetic coating
1881wherein the coating consists of chelates, i.e. chelating group complexing a (super)(para)magnetic ion, bound to the surface
Applicants
  • 中南大学 CENTRAL SOUTH UNIVERSITY [CN]/[CN] (AllExceptUS)
  • 黄苏萍 HUANG, Suping [CN]/[CN] (UsOnly)
  • 周科朝 ZHOU, Kechao [CN]/[CN] (UsOnly)
  • 王维 WANG, Wei [CN]/[CN] (UsOnly)
  • 李志友 LI, Zhiyou [CN]/[CN] (UsOnly)
Inventors
  • 黄苏萍 HUANG, Suping
  • 周科朝 ZHOU, Kechao
  • 王维 WANG, Wei
  • 李志友 LI, Zhiyou
Agents
  • 中南大学专利中心 CENTRAL SOUTH UNIVERSITY PATENT CENTER
Priority Data
200910043384.413.05.2009CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) NUCLEAR MAGNETIC RESONANCE CONTRAST AGENT FOR LIVER OR SPLEEN AND PREPARATION METHOD THEREOF
(FR) AGENT DE CONTRASTE POUR IMAGERIE PAR RÉSONANCE MAGNÉTIQUE NUCLÉAIRE DU FOIE OU DE LA RATE, ET PROCÉDÉ PERMETTANT SA PRÉPARATION
(ZH) 用于肝或脾脏的核磁共振对比剂及其制备方法
Abstract
(EN)
A nuclear magnetic resonance contrast agent and a method of its preparation are disclosed. The contrast agent is a granule of hydroxyapatite (Ca10(PO4)6(OH)2, "HA") coated or grafted by gadopentetate dimeglumine(Gd-DTPA) with a diameter less than 1000 nm. The surface of the granule is further modified by human serum albumin, polyethyleneimine or polyethylene glycol in order to obtain a stably dispersed colloidal solution. The contrast agent is used to enhance the effect of contrast imaging of liver or spleen of human or animals.
(FR)
La présente invention concerne un agent de contraste pour imagerie par résonance magnétique nucléaire et un procédé permettant sa préparation. L'agent de contraste est une granule d'hydroxyapatite (Ca10(PO4)6(OH)2, "HA") revêtue ou greffée par de la gadopentétate diméglumine (Gd-DTPA) de diamètre inférieur à 1000 nm. La surface de la granule est en outre modifiée par de l'albumine sérique humaine, de la polyéthylèneimine ou du polyéthylène glycol afin d'obtenir une solution colloïdale dispersée de manière stable. L'agent de contraste est employé pour améliorer l'effet d'imagerie par contraste du foie ou de la rate chez l'homme ou l'animal.
Latest bibliographic data on file with the International Bureau