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1. WO2011002926 - ISOLATED ADULT CELLS, ARTIFICIAL ORGANS,REHABILITATED ORGANS, RESEARCH ROOLS, ORGAN ENCASEMENTS, ORGAN PERFUSION SYSTEMS, AND METHODS FOR PREPARING AND UTILIZING THE SAME

Publication Number WO/2011/002926
Publication Date 06.01.2011
International Application No. PCT/US2010/040663
International Filing Date 30.06.2010
IPC
C12N 5/07 2010.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
A01N 1/02 2006.01
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
1Preservation of bodies of humans or animals, or parts thereof
02Preservation of living parts
A61F 2/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
2Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
02Prostheses implantable into the body
CPC
A01N 1/021
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
1Preservation of bodies of humans or animals, or parts thereof
02Preservation of living parts
0205Chemical aspects
021Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
A01N 1/0247
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
1Preservation of bodies of humans or animals, or parts thereof
02Preservation of living parts
0236Mechanical aspects
0242Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
0247for perfusion, i.e. for circulating fluid through organs, blood vessels or other living parts
A61K 35/407
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
37Digestive system
407Liver; Hepatocytes
A61M 1/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
1Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
14Dialysis systems; Artificial kidneys; Blood oxygenators; ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for haemofiltration, pheris
C12N 5/067
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor;
06Animal cells or tissues; Human cells or tissues
0602Vertebrate cells
067Hepatocytes
Applicants
  • THE GENERAL HOSPITAL CORPORATION [US]/[US] (AllExceptUS)
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY [US]/[US] (AllExceptUS)
  • YARMUSH, Martin [US]/[US] (UsOnly)
  • UYGUN, Basak, E. [TR]/[US] (UsOnly)
  • UYGUN, Korkut [TR]/[US] (UsOnly)
  • IZAMIS, Maria, Louisa [CY]/[US] (UsOnly)
  • SOTO-GUTIERREZ, Alejandro [MX]/[US] (UsOnly)
  • TOLBOOM, Herman [NL]/[CH] (UsOnly)
  • YAGI, Hiroshi [JP]/[US] (UsOnly)
  • SHULMAN, Carley [US]/[US] (UsOnly)
  • MILWID, Jack [US]/[US] (UsOnly)
Inventors
  • YARMUSH, Martin
  • UYGUN, Basak, E.
  • UYGUN, Korkut
  • IZAMIS, Maria, Louisa
  • SOTO-GUTIERREZ, Alejandro
  • TOLBOOM, Herman
  • YAGI, Hiroshi
  • SHULMAN, Carley
  • MILWID, Jack
Agents
  • LAURO, Peter C.
Priority Data
61/222,26601.07.2009US
61/304,86016.02.2010US
61/330,95904.05.2010US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ISOLATED ADULT CELLS, ARTIFICIAL ORGANS,REHABILITATED ORGANS, RESEARCH ROOLS, ORGAN ENCASEMENTS, ORGAN PERFUSION SYSTEMS, AND METHODS FOR PREPARING AND UTILIZING THE SAME
(FR) CELLULES ADULTES ISOLÉES, ORGANES ARTIFICIELS, ORGANES RÉHABILITÉS, OUTILS DE RECHERCHE, REVÊTEMENTS D'ORGANE, SYSTÈMES DE PERFUSION D'ORGANE, ET MÉTHODES DE PRÉPARATION ET D'UTILISATION DE CEUX-CI
Abstract
(EN)
One aspect of the invention provides a method for harvesting adult cells from an organ. The method includes perfusing the organ with a perfusate and isolating adult cells from the organ, thereby harvesting the adult cells from the organ. Another aspect of the invention provides a method for rehabilitating an organ. The method includes: dividing the organ into a first portion and a second portion, perfusing the first portion with a decellularization medium, isolating adult cells from the second portion, and recellularizing the first portion with a suspension of the adult cells, thereby rehabilitating the organ.
(FR)
La présente invention concerne, dans un aspect, une méthode de récolte de cellules adultes provenant d'un organe. Ladite méthode comprend la perfusion de l'organe au moyen d'un liquide de perfusion et l'isolation de cellules adultes provenant de l'organe, ce qui permet la récolte de cellules adultes provenant de l'organe. L'invention concerne, dans un autre aspect, une méthode de réhabilitation d'un organe. Ladite méthode comprend les éléments suivants : division de l'organe en une première partie et en une seconde partie ; perfusion de la première partie au moyen d'un milieu de décellularisation ; isolement de cellules adultes provenant de la seconde partie ; et recellularisation de la première partie avec une suspension des cellules adultes, permettant ainsi la réhabilitation de l'organe.
Also published as
Latest bibliographic data on file with the International Bureau