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1. WO2011002523 - PHOSPHORUS CONTAINING QUINAZOLINE COMPOUNDS AND METHODS OF USE

Publication Number WO/2011/002523
Publication Date 06.01.2011
International Application No. PCT/US2010/001897
International Filing Date 02.07.2010
IPC
A01N 43/54 2006.01
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
43Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
48having rings with two nitrogen atoms as the only ring hetero atoms
541,3-Diazines; Hydrogenated 1,3-diazines
A61K 31/517 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
517ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
CPC
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C07F 9/65128
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
645having two nitrogen atoms as the only ring hetero atoms
6509Six-membered rings
6512having the nitrogen atoms in positions 1 and 3
65128condensed with carbocyclic rings or carbocyclic ring systems
C07F 9/65586
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
6558containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
65586at least one of the hetero rings does not contain nitrogen as ring hetero atom
C07F 9/65685
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
6564having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
6568having phosphorus atoms as the only ring hetero atoms
65685the ring phosphorus atom being part of a phosphine oxide or thioxide
C07F 9/657181
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
6564having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
6571having phosphorus and oxygen atoms as the only ring hetero atoms
657163the ring phosphorus atom being bound to at least one carbon atom
657181the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
Applicants
  • NEWGEN THERAPEUTICS, INC. [US]/[US] (AllExceptUS)
  • SHEN, Wang [US]/[US] (UsOnly)
  • ZHANG, Aimin [CN]/[US] (UsOnly)
  • FAN, Junfa [CN]/[US] (UsOnly)
  • ZHENG, Xiaoling [US]/[US] (UsOnly)
Inventors
  • SHEN, Wang
  • ZHANG, Aimin
  • FAN, Junfa
  • ZHENG, Xiaoling
Agents
  • TIAN, Zong-Qiang, Bill
Priority Data
61/222,55102.07.2009US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PHOSPHORUS CONTAINING QUINAZOLINE COMPOUNDS AND METHODS OF USE
(FR) COMPOSÉS QUINAZOLINE CONTENANT DU PHOSPHORE ET PROCÉDÉS D'UTILISATION
Abstract
(EN)
Disclosed are novel quinazoline derivatives containing phosphorus substitutions and methods for the treatment of hyperproliferative diseases (e.g. cancer) using the compounds. These compounds are type I receptor protein kinase inhibitors useful in treating disorders related to abnormal protein kinase activities such as cancer and inflammation in mammals. Also disclosed are pharmaceutical compositions containing the compounds, methods for the preparation of the compounds and their pharmaceutically acceptable salts.
(FR)
L'invention porte sur de nouveaux dérivés de quinazoline contenant des substitutions de phosphore et sur des procédés pour le traitement de maladies hyperprolifératives (par exemple le cancer) à l'aide des composés. Ces composés sont des inhibiteurs de récepteur protéine kinase de type I utiles dans le traitement de troubles liés à des activités protéine kinase anormales telles que le cancer et une inflammation chez des mammifères. L'invention port également sur des compositions pharmaceutiques contenant les composés, sur des procédés de préparation des composés et sur leurs sels pharmaceutiquement acceptables.
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