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1. WO2011001214 - SURFACE AMORPHIZATION OF PHENPROBAMATE

Note: Text based on automatic Optical Character Recognition processes. Please use the PDF version for legal matters

[ EN ]

Claims

[Claim 1] A pharmaceutical composition of phenprobamate characterized in that ;

- Phenprobamate is coated with binder mixture or,

- Mixtures of phenprobamate and an excipient or excipients are coated with binder mixture or,

- Phenprobamate is granulated with binder or binders in which granulation is wet granulation or

- Mixture of phenprobamate and an excipient or mixture of phenprobamate and excipients are granulated in which granulation is wet granulation.

[Claim 2] As claimed in claim 1, binder mixtures are solution or suspension

including binder or mixtures of binders

[Claim 3] As claimed in claim 1, binder is selected from group consisting of starch, polyethyleneglycol, microcrystalline cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose,carboxymethylcellulose, sodium alginate,ethylcellulose, polyvinylpyrrolidone, pregelatinized starch, gelatin or mixtures thereof.

[Claim 4] As claimed in claim 2, binder solution or binder suspension

comprising;

- a binder or mixtures of binders and ,

- water or organic solvent or mixture of water and an organic solvent or solvents or mixture of organic solvents

- optionally further excipients.

[Claim 5] As claimed in claim 4, organic solvent is selected from group

consisting of methanol, ethanol, propyl alcohol, isopropyl alcohol, 2-methyl-l-propanol, acetone, methyl ethyl ketone, methyl isobutyl ketone, methyl acetate, ethyl acetate, propyl acetate, isopropyl acetate, ethyl formate, heptane, dichloromethane or mixtures thereof.

[Claim 6] A pharmaceutical composition of phenprobamate in combination with an active pharmaceutical ingredient or ingredients characterized in that

- Phenprobamate alone is coated with binder mixture or,

- Mixtures of phenprobamate and an active pharmaceutical ingredient or ingredients are coated with binder mixture or,

- Mixtures of phenprobamate and an active pharmaceutical ingredient or ingredients and an excipient or excipients arecoated withbinder mixture or,

- Phenprobamate is granulated with binder or binders in which

granulation is wet granulation or

- Mixtures of phenprobamate and an active pharmaceutical ingredient or ingredients are granulated with binder or binders in which granulation is wet granulation or,

- Mixture of phenprobamate and an active pharmaceutical ingredient or ingredients and an excipient or excipients are granulated in which granulation is wet granulation.

[Claim 7] As claimed in claim 6, binder mixtures are solution or suspension

including binder or mixtures of binders

[Claim 8] As claimed in claim 6, binder is selected from group consisting of starch, polyethyleneglycol, microcrystalline cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose,carboxymethylcellulose, sodium alginate,ethylcellulose, polyvinylpyrrolidone, pregelatinized starch, gelatin or mixtures thereof.

[Claim 9] As claimed in claim 7, binder solution or binder suspension

comprising;

- a binder or mixtures of binders and ,

- water or organic solvent or mixture of water and an organic solvent or solvents or mixture of organic solvents

- optionally further excipients.

[Claim 10] As claimed in claim 9, organic solvent is selected from group

consisting of methanol, ethanol, propyl alcohol, isopropyl alcohol, 2-methyl-l-propanol, acetone, methyl ethyl ketone, methyl isobutyl ketone, methyl acetate, ethyl acetate, propyl acetate, isopropyl acetate, ethyl formate, heptane, dichloromethane or mixtures thereof.