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1. WO2011000407 - LIQUID CHROMATOGRAPHY ADJUSTMENT FOR METHOD-CONFORMALLY COMPENSATING DEVIATIONS FROM IDEAL BEHAVIOR

Publication Number WO/2011/000407
Publication Date 06.01.2011
International Application No. PCT/EP2009/058152
International Filing Date 30.06.2009
IPC
G01N 30/24 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
02Column chromatography
04Preparation or injection of sample to be analysed
24Automatic injection systems
G01N 30/86 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
02Column chromatography
86Signal analysis
G01N 30/88 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
02Column chromatography
88Integrated analysis systems specially adapted therefor, not covered by a single one of groups G01N30/04-G01N30/86146
CPC
G01N 30/24
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
02Column chromatography
04Preparation or injection of sample to be analysed
24Automatic injection systems
G01N 30/86
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
02Column chromatography
86Signal analysis
G01N 30/88
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
02Column chromatography
88Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
Applicants
  • AGILENT TECHNOLOGIES, INC. [US]/[US] (AllExceptUS)
  • CHOIKHET, Konstantin [RU]/[DE] (UsOnly)
  • WITT, Klaus [DE]/[DE] (UsOnly)
Inventors
  • CHOIKHET, Konstantin
  • WITT, Klaus
Agents
  • BARTH, Daniel
Priority Data
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) LIQUID CHROMATOGRAPHY ADJUSTMENT FOR METHOD-CONFORMALLY COMPENSATING DEVIATIONS FROM IDEAL BEHAVIOR
(FR) AJUSTEMENT D'UN DISPOSITIF DE CHROMATOGRAPHIE EN PHASE LIQUIDE POUR COMPENSER LES ÉCARTS PAR RAPPORT À UN COMPORTEMENT IDÉAL TOUT EN RESTANT CONFORME AU PROCÉDÉ
Abstract
(EN)
A liquid chromatography device (200) being controllable for executing a chromatographic method (402) defined by a set of target parameters and by a corresponding target sequence of operation procedures, the device comprising a method execution unit (202) configured for executing the chromatographic method (402) by applying the set of target parameters and by running the corresponding target sequence of operation procedures within the liquid chromatography device (200), a determining unit (204) configured for determining a deviation of an actual result of the chromatographic method (402) from an expected target result, wherein the expected target result of the chromatographic method (402) represents a desired behavior of the liquid chromatography device (200) and wherein the actual result of the chromatographic method (402) is obtained by executing the chromatographic method (402) and represents an actual behavior of the liquid chromatography device (200), and an adjusting unit (206) configured for adjusting at least one operation property of the liquid chromatography device (200) based on the determined deviation to thereby at least partially compensate a difference between the expected target result and the actual result while maintaining the chromatographic method (402) unchanged.
(FR)
Cette invention concerne un dispositif de chromatographie en phase liquide (200) pouvant être commandé pour exécuter un procédé chromatographique (402) défini par un jeu de paramètres cibles et par une séquence cible correspondante de modes opératoires. Le dispositif selon l'invention comprend une unité d'exécution de procédé (202) conçue pour exécuter le procédé chromatographique (402) par application du jeu de paramètres cibles et par exécution de la séquence cible correspondante de modes opératoires dans le dispositif de chromatographie en phase liquide (200), et une unité de détermination (204) conçue pour déterminer un écart d'un résultat réel du procédé chromatographique (402) par rapport à un résultat cible théorique. Le résultat cible théorique du procédé chromatographique (402) représente un comportement recherché du dispositif de chromatographie en phase liquide (200) et le résultat réel du procédé chromatographique (402) est obtenu par exécution du procédé chromatographique (402) et représente le comportement réel du dispositif de chromatographie en phase liquide (200). Le dispositif selon l'invention comprend également une unité d'ajustement (206) conçue pour ajuster au moins une propriété de fonctionnement du dispositif de chromatographie en phase liquide (200) en fonction de l'écart déterminé pour compenser ainsi, au moins partiellement, une différence entre le résultat cible théorique et le résultat réel, tout en gardant le procédé chromatographique (402) inchangé.
Also published as
Latest bibliographic data on file with the International Bureau