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1. WO2011000054 - IMMUNO-CONJUGATES AND METHODS FOR PRODUCING THEM

Publication Number WO/2011/000054
Publication Date 06.01.2011
International Application No. PCT/AU2010/000847
International Filing Date 02.07.2010
IPC
C07K 16/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
C07K 16/18 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
A61K 47/6879
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
68the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
6835the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
6875the antibody being a hybrid immunoglobulin
6879the immunoglobulin having two or more different antigen-binding sites, e.g. bispecific or multispecific immunoglobulin
A61K 51/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51Preparations containing radioactive substances for use in therapy or testing in vivo
02characterised by the carrier ; , i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
04Organic compounds
08Peptides, e.g. proteins ; , carriers being peptides, polyamino acids, proteins
10Antibodies or immunoglobulins; Fragments thereof ; , the carrier being an antibody or an immunoglobulin, or a fragment thereof, e.g. a camelised human single domain antibody, or the Fc fragment of an antibody
A61K 51/1093
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51Preparations containing radioactive substances for use in therapy or testing in vivo
02characterised by the carrier ; , i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
04Organic compounds
08Peptides, e.g. proteins ; , carriers being peptides, polyamino acids, proteins
10Antibodies or immunoglobulins; Fragments thereof ; , the carrier being an antibody or an immunoglobulin, or a fragment thereof, e.g. a camelised human single domain antibody, or the Fc fragment of an antibody
1093conjugates with carriers being antibodies
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Applicants
  • AVIPEP PTY LTD [AU]/[AU] (AllExceptUS)
  • HUDSON, Peter, John [AU]/[AU] (UsOnly)
  • SANDERS, Paul, Robert [AU]/[AU] (UsOnly)
  • TAMVAKIS, Debra [AU]/[AU] (UsOnly)
  • TURATTI, Fabio [IT]/[AU] (UsOnly)
  • WHEATCROFT, Michael, Paul [AU]/[AU] (UsOnly)
  • LEONG, David [AU]/[AU] (UsOnly)
Inventors
  • HUDSON, Peter, John
  • SANDERS, Paul, Robert
  • TAMVAKIS, Debra
  • TURATTI, Fabio
  • WHEATCROFT, Michael, Paul
  • LEONG, David
Agents
  • FB RICE & CO
Priority Data
200990312703.07.2009AU
61/223,35306.07.2009US
61/256,70330.10.2009US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) IMMUNO-CONJUGATES AND METHODS FOR PRODUCING THEM
(FR) IMMUNOCONJUGUÉS ET LEURS PROCÉDÉS DE PRODUCTION
Abstract
(EN)
The present invention provides an isolated protein comprising an immunoglobulin variable region comprising at least two cysteine residues positioned within framework region 1 such that if at least two of the cysteine residues are not conjugated to another compound a disulphide bond forms between the cysteine residues. Preferably the protein comprises an immunoglobulin heavy chain variable region and an immunoglobulin light chain variable region, wherein at least one of the variable regions comprises the two cysteine residues. The present invention also provides a protein that binds to TAG72. The present invention also provides conjugates of the protein and another compound.
(FR)
La présente invention porte sur une protéine isolée qui comporte une région variable d'immunoglobuline comportant au moins deux résidus cystéines positionnés à l'intérieur de la région de cadre 1, de telle sorte que si au moins deux des résidus cystéines ne sont pas conjugués à un autre composé, une liaison bisulfure se forme entre les résidus cystéines. De préférence, la protéine comporte une région variable de chaîne lourde d'immunoglobuline et une région variable de chaîne légère d'immunoglobuline, au moins l'une des régions variables comportant les deux résidus cystéines. La présente invention porte également sur une protéine qui se lie à TAG72. La présente invention porte également sur des conjugués de la protéine et d'un autre composé.
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