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Machine translation
1. (WO2010151827) X-BOX BINDING PROTEINS (XBP-1) VARIANTS AND METHODS OF USING THE SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/151827    International Application No.:    PCT/US2010/040086
Publication Date: 29.12.2010 International Filing Date: 25.06.2010
IPC:
C07H 21/00 (2006.01), C12N 15/00 (2006.01), A61K 31/7088 (2006.01)
Applicants: BAYER HEALTHCARE LLC [US/US]; 555 White Plains Road Tarrytown, New York 10591 (US) (For All Designated States Except US).
KIEWLICH, David [US/US]; (US) (For US Only)
Inventors: KIEWLICH, David; (US)
Agent: SANTOS, Fernando; Bayer HealthCare LLC 800 Dwight Way Berkeley, California 94710 (US)
Priority Data:
61/220,486 25.06.2009 US
Title (EN) X-BOX BINDING PROTEINS (XBP-1) VARIANTS AND METHODS OF USING THE SAME
(FR) VARIANTES DES PROTÉINES DE LIAISON AU PROMOTEUR X-BOX (XBP-1) ET PROCÉDÉS D'UTILISATION CORRESPONDANT
Abstract: front page image
(EN)Provided is a variant of X-box binding protein-1 (Xbp1) that cannot be spliced in response to activation of the UPR. This variant contains a silent mutation which removes the IRE1 recognition site. Also provided is the use of this variant in the treatment of UPR-activating diseases.
(FR)La présente invention concerne une variante de la protéine de liaison au promoteur X-box (Xbp-1) qui ne peut pas être épissée en réaction à l'activation d'UPR. Cette variante contient une mutation muette qui fait disparaître le site de reconnaissance IRE1. L'invention concerne également l'utilisation de cette variante pour le traitement d'affections à activation d'UPR.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)