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Machine translation
1. (WO2010151711) PRODRUGS OF NH-ACIDIC COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/151711    International Application No.:    PCT/US2010/039878
Publication Date: 29.12.2010 International Filing Date: 24.06.2010
IPC:
A01N 43/00 (2006.01)
Applicants: ALKERMES, INC. [US/US]; 852 Winters Street Waltham, MA 02451 (US) (For All Designated States Except US).
BLUMBERG, Laura, Cook [US/US]; (US) (For US Only).
REMENAR, Julius, F. [US/US]; (US) (For US Only).
ALMARSSON, Örn [US/US]; (US) (For US Only).
ZEIDAN, Tarek, A. [LB/US]; (US) (For US Only)
Inventors: BLUMBERG, Laura, Cook; (US).
REMENAR, Julius, F.; (US).
ALMARSSON, Örn; (US).
ZEIDAN, Tarek, A.; (US)
Agent: ISSAC, Roy, P.; Elmore Patent Law Group, PC 515 Groton Road, Unit 1R Westford, MA 01886 (US)
Priority Data:
61/293,087 07.01.2010 US
61/293,133 07.01.2010 US
61/220,480 25.06.2009 US
Title (EN) PRODRUGS OF NH-ACIDIC COMPOUNDS
(FR) PROMÉDICAMENTS DE COMPOSÉS NH ACIDES
Abstract: front page image
(EN)The invention provides a method of sustained delivery of a lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug by administering to a patient an effective amount of a prodrug compound of the invention wherein upon administration to the patient, release of the parent drug from the prodrug is sustained release. Prodrug compounds suitable for use in the methods of the invention are labile conjugates of parent drugs that are derivatized through carbonyl linked prodrug moieties. The prodrug compounds of the invention can be used to treat any condition for which the lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug is useful as a treatment.
(FR)L'invention concerne une méthode de distribution prolongée d'un médicament parent contenant du lactame, de l'imide, de l'amide, du sulfonamide, du carbamate ou de l'urée par administration à un patient d'une quantité efficace d'un composé de promédicament objet de l'invention. Lors de l'administration du composé de promédicament au patient, la libération du médicament parent à partir dudit promédicament se produit sous forme prolongée. Les composés de promédicament appropriés pour être utilisés dans les méthodes de l'invention sont des conjugués labiles de médicaments parents qui sont dérivés avec des fractions de promédicament à liaison carbonyle. Les composés de promédicament de l'invention peuvent être utilisés pour traiter des troubles quelconques pour lesquels le médicament parent contenant du lactame, de l'imide, de l'amide, du sulfonamide, du carbamate ou de l'urée constitue un traitement efficace.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)