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1. (WO2010151653) TERPENE GLYCOSIDES AND THEIR COMBINATIONS AS SOLUBILIZING AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/151653    International Application No.:    PCT/US2010/039799
Publication Date: 29.12.2010 International Filing Date: 24.06.2010
IPC:
A61K 47/36 (2006.01)
Applicants: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY & AGRICULTURAL & MECHANICAL COLLEGE [US/US]; LSU AgCenter, 104 Efferson Hall Baton Rouge, LA 70803 (US) (For All Designated States Except US).
LIU, Zhijun [US/US]; (US) (For US Only)
Inventors: LIU, Zhijun; (US)
Agent: DAVIS, Bonnie, J.; Taylor, Porter, Brooks & Phillips L.L.P. P.O. Box 2471 Baton Rouge, LA 70821-2471 (US)
Priority Data:
61/219,973 24.06.2009 US
Title (EN) TERPENE GLYCOSIDES AND THEIR COMBINATIONS AS SOLUBILIZING AGENTS
(FR) GLYCOSIDES TERPÉNIQUES ET LEURS COMBINAISONS SERVANT D'AGENTS DE SOLUBILISATION
Abstract: front page image
(EN)Several terpene glycosides (e.g., mogroside V, paenoiflorin, geniposide, rubusoside, rebaudioside A, steviol monoside and stevioside) were discovered to enhance the solubility of a number of pharmaceutically and medicinally important compounds, including but not limited to, paclitaxel, camptothecin, curcumin, tanshinone HA, capsaicin, cyclosporine, erythromycin, nystatin, itraconazole, celecoxib, clofazimine, digoxin, oleandrin, nifedipine, and amiodarone. The use of the diterpene glycoside rubusoside and monoterpene glycoside paenoiflorin increased solubility in all tested compounds. The terpene glycosides are a naturally occurring class of water solubility-enhancing compounds that are non-toxic and that will be useful as new complexing agents or excipients in the pharmaceutical, agricultural (e.g., solubilizing pesticides), cosmetic and food industries.
(FR)On a découvert plusieurs glycosides terpéniques (par exemple, mogroside V, paenoiflorine, géniposide, rubusoside, rébaudioside A, monoside de stéviol et stévioside) amplifiant la solubilité d'un certain nombre de composés importants de manière pharmaceutique et médicinale, y compris mais sans limitation, le paclitaxel, la camptothécine, la curcumine, la tanshinone HA, la capsaïcine, la cyclosporine, l'érythromycine, la nystatine, l'itraconazole, le celecoxib, la clofazimine, la digoxine, l'oléandrine, la nifédipine, et l'amiodarone. L'utilisation du glycoside diterpénique rubusoside et du glycoside monoterpénique paenoiflorine augmente la solubilité dans tous les composés testés. Les glycosides terpéniques sont une classe naturelle de composés amplifiant la solubilité dans l'eau, qui sont non toxiques et qui seront utiles comme nouveaux agents complexants ou excipients dans les industries pharmaceutiques, agricoles (par exemple, solubilisation des pesticides), cosmétiques et alimentaires.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)