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1. (WO2010151601) OXO-HETEROCYCLE FUSED PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/151601    International Application No.:    PCT/US2010/039685
Publication Date: 29.12.2010 International Filing Date: 23.06.2010
IPC:
A01N 43/54 (2006.01)
Applicants: GENENTECH, INC. [US/US]; 1 DNA Way South San Francisco, California 94080 (US) (For All Designated States Except US).
BERGERON, Philippe [CA/US]; (US) (For US Only).
COHEN, Frederick [US/US]; (US) (For US Only).
ESTRADA, Anthony [US/US]; (US) (For US Only).
KOEHLER, Michael F.T. [US/US]; (US) (For US Only).
LEE, Wendy [US/US]; (US) (For US Only).
LY, Cuong [US/US]; (US) (For US Only).
LYSSIKATOS, Joseph P. [US/US]; (US) (For US Only).
PEI, Zhonghua [US/US]; (US) (For US Only).
ZHAO, Xianrui [CN/US]; (US) (For US Only)
Inventors: BERGERON, Philippe; (US).
COHEN, Frederick; (US).
ESTRADA, Anthony; (US).
KOEHLER, Michael F.T.; (US).
LEE, Wendy; (US).
LY, Cuong; (US).
LYSSIKATOS, Joseph P.; (US).
PEI, Zhonghua; (US).
ZHAO, Xianrui; (US)
Agent: CHI, I. Shannon; Genentech, Inc. 1 DNA Way, MS-49 South San Francisco, California 94080 (US)
Priority Data:
61/220,011 24.06.2009 US
61/252,284 16.10.2009 US
Title (EN) OXO-HETEROCYCLE FUSED PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE
(FR) COMPOSÉS PYRIMIDINE FUSIONNÉS À OXO-HÉTÉROCYCLES, COMPOSITIONS ET PROCÉDÉS D'UTILISATION
Abstract: front page image
(EN)Disclosed are compounds of Formula (I), including steroisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, that are useful in modulating PIKK related kinase signaling, e.g., mTOR, and for the treatment of diseases (e.g., cancer) that are mediated at least in part by the dysregulation of the PIKK signaling pathway (e.g., mTOR). Formula (I).
(FR)L'invention concerne des composés représentés par la formule (I), comprenant des stéréo-isomères, des isomères géométriques, des tautomères, des solvats, des métabolites et des sels pharmaceutiquement acceptables de ceux-ci, qui sont utilisés pour moduler une signalisation de kinase relative à PIKK, par exemple mTOR, et pour traiter des maladies (par exemple, le cancer) qui sont induites au moins partiellement par la dérégulation de la voie de signalisation de PIKK (par exemple, mTOR).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)