WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2010151005) INJECTABLE COMPOSITION CONTAINING HYDROXYCHLOROQUINE FOR LOCAL ADMINISTRATION FOR TREATING CANCER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/151005    International Application No.:    PCT/KR2010/003938
Publication Date: 29.12.2010 International Filing Date: 18.06.2010
IPC:
A61K 9/08 (2006.01), A61P 35/00 (2006.01), A61K 31/44 (2006.01)
Applicants: YEO, Oh-Young [KR/KR]; (KR)
Inventors: YEO, Oh-Young; (KR)
Agent: LEE, Byung-Hyun; #705, New-Seoul Bldg. 828-8, Yeoksam-dong, Kangnam-gu Seoul 135-080 (KR)
Priority Data:
10-2009-0056251 24.06.2009 KR
Title (EN) INJECTABLE COMPOSITION CONTAINING HYDROXYCHLOROQUINE FOR LOCAL ADMINISTRATION FOR TREATING CANCER
(FR) COMPOSITION INJECTABLE CONTENANT DE L'HYDROXYCHLOROQUINE POUR ADMINISTRATION LOCALE, UTILISÉE POUR LE TRAITEMENT DU CANCER
(KO) 하이드록시클로로퀸을 포함하는 항암 치료를 위한 국소 투여용 주사제 조성물
Abstract: front page image
(EN)The present invention relates to an injectable composition containing hydroxychloroquine for local administration for treating cancer. An anticancer composition according to the present invention exhibits an IC50 value for sarcoma 180, obtained through an in vitro MTT assay, which is approximately 10 times lower than that of cisplatin, and thus exhibits superior cytotoxic effects. In addition, the anticancer composition according to the present invention not only exhibits dose-dependant effects on solid tumors caused by sarcoma 80 in vivo but also exhibits the effect of an elongated life against ascites tumors caused by sarcoma 80.
(FR)L'invention concerne une composition injectable contenant de l'hydroxychloroquine pour administration locale, utilisée pour le traitement du cancer. La composition anti-cancer selon l'invention présente une valeur de CI50 pour le sarcome 180, obtenue par l'intermédiaire d'un dosage MTT in vitro, approximativement 10 fois inférieure à celle du cisplatine, et présente par conséquent des effets cytotoxiques supérieurs. En outre, la composition anti-cancer selon l'invention présente non seulement des effets dépendant de la dose sur des tumeurs solides causées par le sarcome 80 in vivo mais également une durée de vie prolongée vis-à-vis des tumeurs ascitiques provoquées par le sarcome 80.
(KO)본 발명은 하이드록시클로로퀸(hydroxychloroquine)을 포함하는 항암 치료를 위한 국소 투여용 주사제 조성물에 관한 것으로, 본 발명에 따른 항암제 조성물은 in vitro에서 MTT assay를 통한 sarcoma 180에 대한 IC50 값이 시스플라틴에 비하여 10배 정도 낮은 값을 보여 우수한 세포독성 효과를 가지며, 또한 in vivo에서도 sarcoma 80에 의해 유발된 고형암에 대하여 용량 의존적 효과를 나타낼 뿐 아니라, sarcoma 80에 의해 유발된 복수암에 대하여 수명 연장 효과가 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)