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1. (WO2010150982) RECOMBINANT HEMAGGLUTININ PROTEIN HAVING SUPERIOR BIOCOMPATIBILITY FOR AN INFLUENZA VIRUS VACCINE, AND METHOD FOR PREPARING BIODEGRADABLE PLGA MICROSPHERES CONTAINING SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/150982    International Application No.:    PCT/KR2010/003291
Publication Date: 29.12.2010 International Filing Date: 25.05.2010
IPC:
A61K 38/16 (2006.01), A61K 39/145 (2006.01), A61K 39/42 (2006.01), A61K 9/16 (2006.01), C07K 14/11 (2006.01), A61P 31/12 (2006.01)
Applicants: HANBAT NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION [KR/KR]; San 16-1 Deongmyeong-dong, Yuseong-gu Daejeon 305-719 (KR) (For All Designated States Except US).
KIM, Chang Sup [KR/KR]; (KR) (For US Only).
KIM, Sang Hern [KR/KR]; (KR) (For US Only).
JANG, Yong [KR/KR]; (KR) (For US Only)
Inventors: KIM, Chang Sup; (KR).
KIM, Sang Hern; (KR).
JANG, Yong; (KR)
Agent: CHOI, Kyu Whan; GREEN International Patent & Law Office 12th Floor, 949, Dunsan-dong, Seo-gu Daejeon 302-120 (KR)
Priority Data:
10-2009-0056025 23.06.2009 KR
10-2009-0056027 23.06.2009 KR
Title (EN) RECOMBINANT HEMAGGLUTININ PROTEIN HAVING SUPERIOR BIOCOMPATIBILITY FOR AN INFLUENZA VIRUS VACCINE, AND METHOD FOR PREPARING BIODEGRADABLE PLGA MICROSPHERES CONTAINING SAME
(FR) PROTÉINE D'HÉMAGGLUTININE RECOMBINÉE À BIOCOMPATIBILITÉ ÉLEVÉE POUR VACCIN CONTRE LE VIRUS DE LA GRIPPE, ET PROCÉDÉ DE PRÉPARATION DE MICROSPHÈRES DE PLGA CONTENANT CETTE PROTÉINE
(KO) 안전성이 뛰어난 인플루엔자 바이러스 백신용 재조합 헤마글루티닌 단백질 및 이를 함유하는 생분해성 PLGA 미립자의 제조 방법
Abstract: front page image
(EN)The present invention relates to a recombinant hemagglutinin protein serving as an antigenic epitope for an influenza virus vaccine, which lacks or has a low membrane fusion function, and thus has superior biocompatibility, to a method for preparing poly(lactic-co-glycolic acid) (PLGA) containing said recombinant hemagglutinin protein, and to PLGA microspheres prepared by the method.
(FR)L'invention porte sur une protéine d'hémagglutinine recombinée servant d'épitope antigénique pour un vaccin contre le virus de la grippe, ladite protéine ayant une fonction de fusion membranaire inexistante ou faible, ce qui lui confère une biocompatibilité accrue, sur un procédé pour préparer un poly(acide lactique-co-glycolique ) (PLGA) contenant ladite protéine d'hémagglutinine recombinée, ainsi que sur des microsphères de PLGA préparées au moyen dudit procédé.
(KO)본 발명은 막 융합 (membrane fusion) 기능이 결여 또는 저하되어 생체 안전성이 뛰어난 인플루엔자 바이러스 백신용 항원성 에피토프 (antigenic epitope)로서의 재조합 HA (hemagglutinin) 단백질, 상기 재조합 HA 단백질을 함유하는 PLGA [poly(lactic-co-glycolic acid)] 미립자를 제조하는 방법 및 상기 방법에 의해 제조된 인플루엔자 바이러스 백신용 PLGA 미립자에 관한 것이다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)