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1. (WO2010150094) MESENCHYMAL STEM CELLS GROWN UNDER HYPOXIC CONDITIONS: COMPOSITIONS, METHODS AND USES THEREFOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/150094    International Application No.:    PCT/IB2010/001559
Publication Date: 29.12.2010 International Filing Date: 28.06.2010
IPC:
C12N 5/0775 (2010.01)
Applicants: LIFE & LIGHT LIMITED [GB/GB]; Third Floor Poland Street London W1F 8QE (GB) (For All Designated States Except US).
VALORANI, Maria, Giuditta [IT/GB]; (GB) (For US Only)
Inventors: VALORANI, Maria, Giuditta; (GB)
Agent: BROWN, David, Leslie; Haseltine Lake LLP Redcliff Quay 120 Redcliff Street Bristol BS1 6HU (GB)
Priority Data:
61/269,603 26.06.2009 US
Title (EN) MESENCHYMAL STEM CELLS GROWN UNDER HYPOXIC CONDITIONS: COMPOSITIONS, METHODS AND USES THEREFOR
(FR) CELLULES SOUCHES MÉSENCHYMATEUSES CULTIVÉES DANS DES CONDITIONS HYPOXIQUES : COMPOSITIONS, PROCÉDÉS ET UTILISATIONS DE CELLES-CI
Abstract: front page image
(EN)Methods of forming ex vivo cell cultures comprising differentiated mesenchymal lineage cells are disclosed. These methods comprise a) providing a cell culture comprising a plurality of mesenchymal stem cells (MSCs); b) subjecting the MSCs to hypoxic conditions; and c) subsequent to b), subjecting the MSCs to normoxic conditions. Enhanced differentiation of various mesenchymal lineage cells can be achieved for mammalian cells such as murine cells or human cells.
(FR)L'invention porte sur des procédés de formation de cultures cellulaires ex vivo comprenant des cellules de lignées mésenchymateuses différentiées. Ces procédés comprennent les étapes consistant à a) fournir une culture cellulaire comprenant une pluralité de cellules souches mésenchymateuses (MSC) ; (b) soumettre les MSC à des conditions hypoxiques ; et c) ultérieurement à b), soumettre les MSC à des connexions normoxiques. Une différentiation améliorée de diverses cellules de lignées mésenchymateuses peut être réalisée pour des cellules mammifères telles que des cellules murines ou des cellules humaines.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)