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1. WO2010150014 - 5R- 5 -DEUTERATED GLITAZONES FOR RESPIRATORY DISEASE TREATMENT

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Publication Number WO/2010/150014
Publication Date 29.12.2010
International Application No. PCT/GB2010/051044
International Filing Date 24.06.2010
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425
Thiazoles
426
1,3-Thiazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425
Thiazoles
427
not condensed and containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4427
containing further heterocyclic ring systems
4439
containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506
not condensed and containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
513
having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06
Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
06
Antiasthmatics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
08
Bronchodilators
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
A61K 31/426 (2006.01)
A61K 31/427 (2006.01)
A61K 31/4439 (2006.01)
A61K 31/506 (2006.01)
A61K 31/513 (2006.01)
A61K 45/06 (2006.01)
CPC
A61K 31/426
A61K 31/427
A61K 31/4439
A61K 31/506
A61K 31/513
A61K 9/0043
Applicants
  • PULMAGEN THERAPEUTICS (INFLAMMATION) LIMITED [GB/GB]; Fulmer Hall Windmill Road Fulmer Slough Berkshire SL3 6HD, GB (AllExceptUS)
  • FINCH, Harry [GB/GB]; GB (UsOnly)
  • SAJAD, Mohammed [GB/GB]; GB (UsOnly)
  • FORREST, Andrew [GB/GB]; GB (UsOnly)
  • VAN NIEL, Monique Bodil [NL/GB]; GB (UsOnly)
Inventors
  • FINCH, Harry; GB
  • SAJAD, Mohammed; GB
  • FORREST, Andrew; GB
  • VAN NIEL, Monique Bodil; GB
Agents
  • SIMCOX, Michael; D. Young & Co LLP 120 Holborn London EC1N 2DY, GB
Priority Data
0910944.824.06.2009GB
1001903.205.02.2010GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) 5R- 5 -DEUTERATED GLITAZONES FOR RESPIRATORY DISEASE TREATMENT
(FR) GLITAZONES 5R-5–DEUTÉRÉS POUR LE TRAITEMENT DE MALADIES RESPIRATOIRES
Abstract
(EN)
A composition comprising a 5R-5-deuterated glitazone or a salt thereof, in which composition the 5R-5 deuterated glitazone component includes less than 5% by weight in total of 5R-5-protonated glitazone, 5S-5-protonated glitazone and 5S-5- deuterated glitazone. The glitazone may be rosiglitazone or pioglitazone. Compositions may be for pulmonary inhalation for treatment of Pulmonary inflammatory disease.
(FR)
L'invention porte sur une composition comprenant un glitazone 5R-5-deutéré ou un sel de celui-ci, dans laquelle composition le constituant glitazone 5R-5-deutéré représente moins de 5 % en poids du total de glitazone 5R-5-protoné, de glitazone 5S-5-protoné et de glitazone 5S-5-deutéré. Le glitazone peut être du rosiglitazone ou du pioglitazone. Les compositions peuvent être destinées à une inhalation pulmonaire pour le traitement d'une maladie inflammatoire pulmonaire.
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