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Pub. No.:    WO/2010/149016    International Application No.:    PCT/CN2010/074202
Publication Date: 29.12.2010 International Filing Date: 22.06.2010
C07K 7/06 (2006.01), C12P 21/02 (2006.01), C07K 1/22 (2006.01), A61K 38/08 (2006.01), A61P 31/04 (2006.01), C12N 1/21 (2006.01), C12R 1/01 (2006.01)
Applicants: SHANGHAI HEALTH CREATION CENTER FOR BIOPHARMACEUTICAL R & D LTD. CO. [CN/CN]; 5th Floor, Building 8 200 Niudun Road, Zhangjiang Hi-Tech Park, Pudong District Shanghai 201203 (CN) (For US Only).
ZHEJIANG MEDICINE CO., LTD. XINCHANG PHARMACEUTICAL FACTORY [CN/CN]; 59 Huan Cheng Dong Road Xinchang, Zhejiang 312500 (CN) (For All Designated States Except US).
SHANGHAI INSTITUTES FOR BIOLOGICAL SCIENCES OF CHINESE ACADEMY OF SCIENCES [CN/CN]; 320 Yueyang Road, Xuhui District Shanghai 200031 (CN) (For All Designated States Except US).
GE, Mei [CN/CN]; (CN) (For US Only).
HUANG, He [CN/CN]; (CN) (For US Only).
WEI, Wei [CN/CN]; (CN) (For US Only).
RUAN, Lingao [CN/CN]; (CN) (For US Only).
YANG, Sheng [CN/CN]; (CN) (For US Only).
ZHU, Li [CN/CN]; (CN) (For US Only).
JIANG, Weihong [CN/CN]; (CN) (For US Only).
CHEN, Daijie [CN/CN]; (CN) (For US Only).
LUO, Minyu [CN/CN]; (CN) (For US Only).
YANG, Zhijun [CN/CN]; (CN) (For US Only).
XIA, Xing [CN/CN]; (CN) (For US Only).
LI, Qiushuang [CN/CN]; (CN) (For US Only).
WANG, Tianjiao [CN/CN]; (CN) (For US Only).
YIN, Yu [CN/CN]; (CN) (For US Only).
JIN, Wenxiang [CN/CN]; (CN) (For US Only).
YANG, Tian [CN/CN]; (CN) (For US Only)
Inventors: GE, Mei; (CN).
HUANG, He; (CN).
WEI, Wei; (CN).
RUAN, Lingao; (CN).
YANG, Sheng; (CN).
ZHU, Li; (CN).
JIANG, Weihong; (CN).
CHEN, Daijie; (CN).
LUO, Minyu; (CN).
YANG, Zhijun; (CN).
XIA, Xing; (CN).
LI, Qiushuang; (CN).
WANG, Tianjiao; (CN).
YIN, Yu; (CN).
JIN, Wenxiang; (CN).
YANG, Tian; (CN)
Agent: SHANGHAI DANROSE & RAYMOND INTELLECTUAL PROPERTY AGENCY CO., LTD.; Room 2106-2107, Junfeng Plaza 1619 Dalian Rd., Hongkou District Shanghai 200086 (CN)
Priority Data:
200910053906.9 26.06.2009 CN
(ZH) 一种新的化合物及其应用
Abstract: front page image
(EN)A compound of formula (I), the preparation methods and use thereof are disclosed. The compound is obtained by fermenting the mutant strain of Amycolatopsis orientalis CGMCC NO: 3053, wherein the bond of the 4-hydroxy of the saccharide group on benzyl hydroxyl of 6-amino acid on the peptide backbone is an axial bond. The compound has a good antibacterial activity and can be used in preparing antibacterial agent.
(FR)L'invention porte sur un composé de formule (I), sur ses procédés de préparation et sur son utilisation. Le composé est obtenu par fermentation de la souche mutante d'Amycolatopsis orientalis CGMCC NO : 3053, où la liaison du 4-hydroxy du groupe saccharide sur le benzyl hydroxyle de l'acide aminé 6 sur le squelette peptidique est une liaison axiale. Le composé a une bonne activité antibactérienne et peut être utilisé dans la préparation d'un agent antibactérien.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)