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1. WO2010148323 - DIAGNOSIS AND TREATMENT OF DISEASES OR DISORDERS ASSOCIATED WITH XENOTROPIC MURINE LEUKEMIA VIRUS-RELATED VIRUS

Publication Number WO/2010/148323
Publication Date 23.12.2010
International Application No. PCT/US2010/039208
International Filing Date 18.06.2010
Chapter 2 Demand Filed 07.01.2011
IPC
G01N 33/48 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
CPC
C12Q 1/701
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
70involving virus or bacteriophage
701Specific hybridization probes
Applicants
  • WHITTEMORE PETERSON INSTITUTE FOR NEURO-IMMUNE DISEASE [US]/[US] (AllExceptUS)
  • MIKOVITS, Judy, A. [US]/[US] (UsOnly)
  • LOMBARDI, Vincent, C. [US]/[US] (UsOnly)
  • RUSCETTI, Sandra, K. [US]/[US] (UsOnly)
  • RUSCETTI, Francis, W. [US]/[US] (UsOnly)
Inventors
  • MIKOVITS, Judy, A.
  • LOMBARDI, Vincent, C.
  • RUSCETTI, Sandra, K.
  • RUSCETTI, Francis, W.
Agents
  • BLOSSER, Harley, G.
Priority Data
12/575,46707.10.2009US
61/225,00013.07.2009US
61/225,87715.07.2009US
61/228,61626.07.2009US
61/228,62427.07.2009US
61/249,48607.10.2009US
61/268,93318.06.2009US
61/318,39229.03.2010US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) DIAGNOSIS AND TREATMENT OF DISEASES OR DISORDERS ASSOCIATED WITH XENOTROPIC MURINE LEUKEMIA VIRUS-RELATED VIRUS
(FR) DIAGNOSTIC ET TRAITEMENT DE MALADIES OU TROUBLES ASSOCIÉS AU VIRUS DE LA LEUCÉMIE MURINE XÉNOTROPE
Abstract
(EN) Methods of detecting, diagnosing, monitoring or managing an XMRV-related neuroimmune disease such as chronic fatigue syndrome or XMRV-related lymphoma such as mantle cell lymphoma in a subject are disclosed. These methods comprise determining presence, absence or quantity an XMRV immunopeptide, an XMRV antigen, or an XMRV nucleic acid in a sample from a subject. Therapeutic methods of treatment with anti-retroviral agents are also disclosed. Further disclosed are assays for testing compounds having activity against XMRV.
(FR) L'invention porte sur des procédés de détection, de diagnostic, de surveillance ou de gestion d'une maladie neuro-immunitaire liée au XMRV telle que le syndrome de fatigue chronique ou un lymphone lié à XMRV tel que le lymphome à cellules du manteau chez un sujet. Ces procédés comprennent la détermination de la présence, de l'absence ou de la quantité d'un immunopeptide XMRV, d'un antigène XMRV ou d'un acide nucléique XMRV dans un échantillon provenant d'un sujet. L'invention porte également sur des procédés thérapeutiques de traitement par des agents anti-rétroviraux. L'invention porte en outre sur des dosages pour tester les composés ayant une activité contre XMRV.
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