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1. (WO2010148197) INHIBITORS OF INFLUENZA VIRUSES REPLICATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/148197    International Application No.:    PCT/US2010/038988
Publication Date: 23.12.2010 International Filing Date: 17.06.2010
IPC:
A61K 31/506 (2006.01), A61P 31/16 (2006.01)
Applicants: VERTEX PHARMACEUTICALS INCORPORATED [US/US]; 130 Waverly Street Cambridge, MA 02139 (US) (For All Designated States Except US).
CHARIFSON, Paul [US/US]; (US) (For US Only).
CLARK, Michael, P. [US/US]; (US) (For US Only).
BANDARAGE, Upul, K. [US/US]; (US) (For US Only).
BETHIEL, Randy, S. [US/US]; (US) (For US Only).
COURT, John, J. [US/US]; (US) (For US Only).
DENG, Hongbo [CN/US]; (US) (For US Only).
DRUTU, Ioana [RO/US]; (US) (For US Only).
DUFFY, John, P. [US/US]; (US) (For US Only).
FARMER, Luc [CA/US]; (US) (For US Only).
GAO, Huai [CN/US]; (US) (For US Only).
GU, Wenxin [CN/US]; (US) (For US Only).
JACOBS, Dylan, H. [US/US]; (US) (For US Only).
KENNEDY, Joseph, M. [US/US]; (US) (For US Only).
LEDEBOER, Mark, W. [US/US]; (US) (For US Only).
LEDFORD, Brian [US/US]; (US) (For US Only).
MALTAIS, Francois [US/US]; (US) (For US Only).
PEROLA, Emanuele [IT/US]; (US) (For US Only).
WANG, Tiansheng [US/US]; (US) (For US Only).
WANNAMAKER, M., Woods [US/US]; (US) (For US Only).
BYRN, Randal [US/US]; (US) (For US Only).
ZHOU, Yi [US/US]; (US) (For US Only).
LIN, Chao [US/US]; (US) (For US Only).
JIANG, Min [US/US]; (US) (For US Only).
JONES, Steven [US/US]; (US) (For US Only).
GERMANN, Ursula, A. [CH/US]; (US) (For US Only)
Inventors: CHARIFSON, Paul; (US).
CLARK, Michael, P.; (US).
BANDARAGE, Upul, K.; (US).
BETHIEL, Randy, S.; (US).
COURT, John, J.; (US).
DENG, Hongbo; (US).
DRUTU, Ioana; (US).
DUFFY, John, P.; (US).
FARMER, Luc; (US).
GAO, Huai; (US).
GU, Wenxin; (US).
JACOBS, Dylan, H.; (US).
KENNEDY, Joseph, M.; (US).
LEDEBOER, Mark, W.; (US).
LEDFORD, Brian; (US).
MALTAIS, Francois; (US).
PEROLA, Emanuele; (US).
WANG, Tiansheng; (US).
WANNAMAKER, M., Woods; (US).
BYRN, Randal; (US).
ZHOU, Yi; (US).
LIN, Chao; (US).
JIANG, Min; (US).
JONES, Steven; (US).
GERMANN, Ursula, A.; (US)
Agent: LIM, Booyong, Shim; Vertex Pharmaceuticals Incorporated 130 Waverly Street Cambridge, MA 02139 (US)
Priority Data:
61/287,781 18.12.2009 US
61/187,713 17.06.2009 US
Title (EN) INHIBITORS OF INFLUENZA VIRUSES REPLICATION
(FR) INHIBITEURS DE LA RÉPLICATION DES VIRUS DE LA GRIPPE
Abstract: front page image
(EN)Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A compound is represented by Structural Formula (IA) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.
(FR)L'invention concerne des méthodes d'inhibition de la réplication des virus de la grippe dans un échantillon biologique ou chez un patient, de réduction de la quantité des virus de la grippe dans un échantillon biologique ou chez un patient, et de traitement de la grippe d'un patient, comprenant l'administration audit échantillon biologique ou patient d'une quantité efficace d'un composé représenté par la formule développée (I) : ou d'un de ses sels pharmaceutiquement acceptables, les valeurs de la formule développée (IA) étant décrites ici. L'invention concerne un composé représenté par la formule développée (IA) ou un de ses sels pharmaceutiquement acceptables, les valeurs de la formule développée (IA) étant décrites ici. L'invention concerne une composition pharmaceutique comprenant une quantité efficace d'un tel composé ou d'un de ses sels pharmaceutiquement acceptables, et un excipient, adjuvant ou véhicule pharmaceutiquement acceptable.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)