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1. (WO2010147169) PHARMACEUTICAL COMPOSITION HAVING IMPROVED SOLUBILITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/147169    International Application No.:    PCT/JP2010/060261
Publication Date: 23.12.2010 International Filing Date: 17.06.2010
IPC:
A61K 31/444 (2006.01), A61K 9/20 (2006.01), A61K 9/32 (2006.01), A61K 9/36 (2006.01), A61K 47/10 (2006.01), A61K 47/26 (2006.01), A61K 47/32 (2006.01), A61K 47/36 (2006.01), A61K 47/38 (2006.01), A61P 7/02 (2006.01), C07D 513/04 (2006.01)
Applicants: DAIICHI SANKYO COMPANY,LIMITED [JP/JP]; 3-5-1,Nihonbashi Honcho,Chuo-ku, Tokyo 1038426 (JP) (For All Designated States Except US).
KAMADA, Makoto; (For US Only).
KIDOKORO,Motonori; (For US Only).
SEKIGUCHI,Gaku; (For US Only)
Inventors: KAMADA, Makoto; .
KIDOKORO,Motonori; .
SEKIGUCHI,Gaku;
Agent: ISHIBASHI Koki; c/o DAIICHI SANKYO COMPANY, LIMITED, 1-16-13,Kitakasai, Edogawa-ku, Tokyo 1340081 (JP)
Priority Data:
2009-145112 18.06.2009 JP
Title (EN) PHARMACEUTICAL COMPOSITION HAVING IMPROVED SOLUBILITY
(FR) COMPOSITION PHARMACEUTIQUE AYANT UNE SOLUBILITÉ AMÉLIORÉE
(JA) 溶出性の改善された医薬組成物
Abstract: front page image
(EN)Provided is a solid pharmaceutical composition that exhibits an inhibitory effect on activated coagulation factor X (FXa), is useful as a preventative and/or therapeutic agent for thrombotic disease, and exhibits good solubility. Said pharmaceutical composition contains a compound represented by formula (I), a pharmacologically-permitted salt thereof, or a solvate of either. The content of the compound represented by formula (I) is at least 0.5% and less than 15% of the total weight of the pharmaceutical composition.
(FR)L'invention porte sur une composition pharmaceutique solide présentant un effet inhibiteur sur le facteur de coagulation activé X (FXa), utile en tant qu'agent préventif et/ou thérapeutique pour une maladie thrombotique, et présentant une bonne solubilité. Ladite composition pharmaceutique contient un composé représenté par la formule (I), un sel pharmacologiquement acceptable de celui-ci ou un solvate de celui-ci ou autre. La teneur en composé représentée par la formule (I) est d'au moins 0,5 % et inférieure à 15 % de la masse totale de la composition pharmaceutique.
(JA) 活性化血液凝固第X因子(FXa)の阻害作用を示し血栓性疾患の予防剤および/または治療剤として有用な式(I)で表される化合物、その薬理上許容される塩またはそれらの溶媒和物を含有する医薬組成物であって、良好な溶出性を示す医薬組成物の提供が求められている。本発明は、式(I)で表される化合物、その薬理上許容される塩またはそれらの溶媒和物を含有する固形の医薬組成物であって、式(I)で表される化合物の含有量が、医薬組成物全重量に対して0.5重量%以上15重量%未満である医薬組成物に関する。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)