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1. (WO2010146605) NOVEL GPR 119 AGONISTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2010/146605    International Application No.:    PCT/IN2010/000418
Publication Date: 23.12.2010 International Filing Date: 17.06.2010
Chapter 2 Demand Filed:    03.01.2011    
C07D 411/12 (2006.01), C07D 411/14 (2006.01), C07D 413/14 (2006.01), C07D 417/14 (2006.01), A61K 31/4535 (2006.01), A61K 31/454 (2006.01), A61K 31/506 (2006.01)
Applicants: CADILA HEALTHCARE LIMITED [IN/IN]; Zydus Tower, Satellite Cross Roads Ahmedabad 380 015 (IN) (For All Designated States Except US).
PINGALI, Harikishore [IN/IN]; (IN) (For US Only).
ZAWARE, Pandurang [IN/IN]; (IN) (For US Only).
JAIN, Mukul [IN/IN]; (IN) (For US Only)
Inventors: PINGALI, Harikishore; (IN).
ZAWARE, Pandurang; (IN).
JAIN, Mukul; (IN)
Agent: SUBRAMANIAM, Hariharan; Nataraj & Associates E-556 Greater Kailash-II New Delhi 110 048 (IN)
Priority Data:
1458/MUM/2009 18.06.2009 IN
Abstract: front page image
(EN)The present invention relates to novel GPR 119 agonists of the general Formula (I), their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, enantiomers, stereoisomers, and polymorphs. The invention also relates to processes for the preparation of the compounds of the invention, pharmaceutical compositions containing the compounds and to methods for treating one or both of diabetes and obesity using the compounds of the invention. The present invention is directed to G-protein coupled receptor (GPCR) agonists that are useful for the treatment of obesity, diabetes and related metabolic disorders.
(FR)La présente invention concerne de nouveaux agonistes de GPR 119 de formule générale (I), leurs sels pharmaceutiquement acceptables, solvates pharmaceutiquement acceptables, énantiomères, stéréoisomères, et polymorphes. L'invention concerne en outre des procédés pour la préparation des composés de l'invention, des compositions pharmaceutiques contenant les composés et des procédés pour traiter l'un ou les deux parmi le diabète et l'obésité en utilisant les composés de l'invention. La présente invention concerne des agonistes de récepteur couplé à la protéine G (GPCR) qui sont utiles pour le traitement de l'obésité, du diabète et des troubles métaboliques associés.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)